Rpgrip1l - Rpgrip1-like Gene

Also Known as Ftm; Nphp8; 4931437C01; 1700047E16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 244585

Summary

Predicted to enable thromboxane A2 receptor binding activity. Acts upstream of or within several processes, including animal organ development; chordate embryonic development; and embryonic limb morphogenesis. Located in ciliary basal body; ciliary transition zone; and cytoplasm. Is expressed in organ of Corti; ovary; and testis. Used to study Joubert syndrome 7 and Meckel syndrome. Human ortholog(s) of this gene implicated in several diseases, including Joubert syndrome 7; Meckel syndrome 5; anencephaly; retinitis pigmentosa 3; and vascular dementia. Orthologous to human RPGRIP1L (RPGRIP1 like). [provided by Alliance of Genome Resources, Apr 2022]

Rpgrip1l Products (1)

mRNA Protein Name
NM_173431.2 NP_775607.2 protein fantom

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21565611 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within brain development IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within camera-type eye development IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within cerebellum development IMP
IMP: Inferred from mutant phenotype
17558409 MGI
acts upstream of or within cilium assembly IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within cochlea development IMP
IMP: Inferred from mutant phenotype
22927466 MGI
acts upstream of or within corpus callosum development IMP
IMP: Inferred from mutant phenotype
17558409 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within embryonic forelimb morphogenesis IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within embryonic hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within establishment of planar polarity IMP
IMP: Inferred from mutant phenotype
22927466 MGI
acts upstream of or within establishment or maintenance of cell polarity IMP
IMP: Inferred from mutant phenotype
22832925 MGI
acts upstream of or within head development IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
17558409 MGI
acts upstream of or within lateral ventricle development IMP
IMP: Inferred from mutant phenotype
17558409 MGI
acts upstream of or within limb morphogenesis IMP
IMP: Inferred from mutant phenotype
17558409 MGI
acts upstream of or within liver development IMP
IMP: Inferred from mutant phenotype
17558409 MGI
acts upstream of or within neural tube patterning IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within non-motile cilium assembly IMP
IMP: Inferred from mutant phenotype
22832925 MGI
acts upstream of or within nose development IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within olfactory bulb development IMP
IMP: Inferred from mutant phenotype
17558409 MGI
acts upstream of or within pericardium development IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
17553904 MGI
acts upstream of or within telencephalon development IMP
IMP: Inferred from mutant phenotype
17558409 MGI
Cellular Component GO Annotation Evidence References Source
located in ciliary basal body IDA
IDA: Inferred from direct assay
17553904 MGI
located in ciliary transition zone IDA
IDA: Inferred from direct assay
22927466 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
21565611 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein fantom

  • RPGR-interacting protein 1-like protein

  • RPGRIP1-like protein

  • fantom

  • nephrocystin-8

Rpgrip1l Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Rpgrip1l Q8CG73 Nphp4 Mus musculus P59240
Anti Tag CoIP
21565611
Intra
Rpgrip1l Q8CG73 Iqcb1 Mus musculus Q8BP00
Anti Tag CoIP
21565611
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12156 RPGRIP1L Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rpgrip1l NCBI NCBI:23322