Igfbp3 - insulin-like growth factor binding protein 3 Gene

Also Known as IGF-BP3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24484

Summary

Enables insulin-like growth factor II binding activity. Involved in several processes, including cellular response to Thyroglobulin triiodothyronine; cellular response to estradiol stimulus; and response to peptide hormone. Located in extracellular space; heterochromatin; and platelet alpha granule. Part of insulin-like growth factor binary complex and insulin-like growth factor ternary complex. Used to study impotence. Biomarker of congenital diaphragmatic hernia; impotence; and obesity. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; Turner syndrome; diabetes mellitus (multiple); prostate cancer; and transitional cell carcinoma. Orthologous to human IGFBP3 (Insulin like growth factor binding protein 3). [provided by Alliance of Genome Resources, Apr 2022]

Igfbp3 Products (1)

mRNA Protein Name
NM_012588.2 NP_036720.2 insulin-like growth factor-binding protein 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables insulin-like growth factor II binding IPI
IPI: Inferred from physical interaction
9346943 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9346943 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to Thyroglobulin triiodothyronine IEP
IEP: Inferred from expression pattern
8674839 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
8674839 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
9449625 RGD
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
22067319 RGD
involved in negative regulation of testosterone secretion IMP
IMP: Inferred from mutant phenotype
25582342 RGD
involved in positive regulation of apoptotic DNA fragmentation IMP
IMP: Inferred from mutant phenotype
15125883 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15935983 RGD
involved in positive regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
15055478 RGD
involved in response to caloric restriction IEP
IEP: Inferred from expression pattern
17635417 RGD
involved in response to growth hormone IEP
IEP: Inferred from expression pattern
19916171 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
22805023 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
8776722 RGD
involved in response to insulin-like growth factor stimulus IEP
IEP: Inferred from expression pattern
8776722 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
15930173 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
7536658 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20042659 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
15990634 RGD
located in heterochromatin IDA
IDA: Inferred from direct assay
15125883 RGD
part of insulin-like growth factor binary complex IDA
IDA: Inferred from direct assay
9346943 RGD
part of insulin-like growth factor ternary complex IDA
IDA: Inferred from direct assay
9346943 RGD
located in platelet alpha granule IDA
IDA: Inferred from direct assay
9449625 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin-like growth factor-binding protein 3

  • IBP-3

  • IGF-binding protein 3

  • IGFBP-3

  • insulin-like growth factor-binding protein (IGF-BP3)

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W074890 Palmitoylglycine Modulator 99.84% Unkown
HY-110135A NBI-31772 hydrate Inhibitor 99.42% Unkown
HY-N3316 Martynoside 99.41% Unkown
HY-RS06626 IGFBP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P10403 IGFBP-3 peptide / Unkown
HY-174650 Human IGFBP3 mRNA / Unkown
HY-182824 Sucrose dilaurate Inducer / Unkown
HY-RS17430 Igfbp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23885 Igfbp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Igfbp3 NCBI NCBI:3486