Ldhb - lactate dehydrogenase B Gene

Also Known as Ldh2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24534

Summary

This gene encodes the B subunit of Lactate Dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have also been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 9. [provided by RefSeq, Feb 2016]

Ldhb Products (3)

mRNA Protein Name
NM_001316333.1 NP_001303262.1 L-lactate dehydrogenase B chain isoform Ldhbx
NM_001316334.1 NP_001303263.1 L-lactate dehydrogenase B chain isoform Ldhb
NM_012595.2 NP_036727.1 L-lactate dehydrogenase B chain isoform Ldhb

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables L-lactate dehydrogenase activity IDA
IDA: Inferred from direct assay
17447164 RGD
enables NAD binding IDA
IDA: Inferred from direct assay
17447164 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
7138505 RGD
enables kinase binding IPI
IPI: Inferred from physical interaction
17572440 RGD
enables lactate dehydrogenase activity IDA
IDA: Inferred from direct assay
7138505 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
7138505 RGD
Biological Process GO Annotation Evidence References Source
involved in NAD metabolic process IDA
IDA: Inferred from direct assay
17447164 RGD
involved in lactate metabolic process IDA
IDA: Inferred from direct assay
17447164 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

L-lactate dehydrogenase B chain

  • LDH heart subunit

  • LDH-B

  • LDH-H

  • Lactate dehydrogenease B

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100742A (R)-GNE-140 Inhibitor 99.77% Unkown
HY-147216 AXKO-0046 Inhibitor 99.77% Unkown
HY-100742B (S)-GNE-140 Inhibitor 99.30% Unkown
HY-118241 GNE-140 Inhibitor 98.43% Unkown
HY-175562 LDH-IN-4 Inhibitor / Unkown
HY-183858 NCATS-SM1440 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ldhb NCBI NCBI:3945