LDHB - lactate dehydrogenase B Gene

Also Known as LDH-B; LDH-H; LDHBD; TRG-5; HEL-S-281

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3945

About LDHB

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:21,635,342-21,657,842 (from NCBI)

This gene has 11 transcripts (splice variants), 279 orthologues, 5 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 475.5), heart (RPKM 454.7) and 21 other tissues.

Summary

This gene encodes the B subunit of Lactate Dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Alternatively spliced transcript variants have been found for this gene. Recent studies have shown that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Mutations in this gene are associated with Lactate Dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Feb 2016]

LDHB Products (6)

mRNA Protein Name
NM_001174097.3 NP_001167568.1 L-lactate dehydrogenase B chain isoform LDHB
NM_001315537.2 NP_001302466.1 L-lactate dehydrogenase B chain isoform LDHBx
NM_001414233.1 NP_001401162.1 L-lactate dehydrogenase B chain isoform 3
NM_001414234.1 NP_001401163.1 L-lactate dehydrogenase B chain isoform 4
NM_001414235.1 NP_001401164.1 L-lactate dehydrogenase B chain isoform 5
NM_002300.8 NP_002291.1 L-lactate dehydrogenase B chain isoform LDHB

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables L-lactate dehydrogenase activity IDA
IDA: Inferred from direct assay
27618187 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence References Source
involved in lactate metabolic process IDA
IDA: Inferred from direct assay
15117937 GOA
involved in pyruvate metabolic process IDA
IDA: Inferred from direct assay
15117937 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane raft IDA
IDA: Inferred from direct assay
25204797 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
27618187 GOA
part of oxidoreductase complex IPI
IPI: Inferred from physical interaction
15117937 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LDHB Protein Structure

Ldh_1_N

Ldh_1_N: lactate/malate dehydrogenase, NAD binding domain (22 - 161)

Ldh_1_C

Ldh_1_C: lactate/malate dehydrogenase, alpha/beta C-terminal domain (165 - 329)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

L-lactate dehydrogenase B chain

  • LDH heart subunit

LDHB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LDHB P07195 LDHA Homo sapiens P00338-3
Y2H Array
25416956
Intra
LDHB P07195 LDHA Homo sapiens P00338-3
Y2H Array
32296183
Intra
LDHB P07195 LDHA Homo sapiens P00338-3
Y2H Prey Pooling
32296183
Intra
LDHB P07195 LDHA Homo sapiens P00338-3
Validated Y2H
25910212
Intra
LDHB P07195 LDHA Homo sapiens P00338-3
Y2H Bait-Prey Pool
25910212
Intra
LDHB P07195 LDHA Homo sapiens P00338-3
Y2H Array
25910212
Intra
LDHB P07195 LDHC Homo sapiens P07864
Anti Tag CoIP
33961781
Intra
LDHB P07195 LDHC Homo sapiens P07864
Anti Tag CoIP
28514442
Intra
LDHB P07195 LDHC Homo sapiens P07864
Anti Tag CoIP
35271311
Intra
LDHB P07195 LDHB Homo sapiens P07195
Y2H Prey Pooling
32296183
Intra
LDHB P07195 LDHA Homo sapiens P00338
Anti Tag CoIP
33961781
Intra
LDHB P07195 LDHB Homo sapiens P07195
Validated Y2H
32296183
Intra
LDHB P07195 LDHB Homo sapiens P07195
Y2H Array
25416956
Intra
LDHB P07195 LDHB Homo sapiens P07195
Y2H Array
25502805
Intra
LDHB P07195 LDHB Homo sapiens P07195
Y2H Array
32296183
Intra
LDHB P07195 LDHA Homo sapiens P00338
Anti Tag CoIP
35271311
Intra
LDHB P07195 LDHB Homo sapiens P07195
Y2H Array
31515488
Intra
LDHB P07195 HTT Homo sapiens P42858
Validated Y2H
32814053
Intra
LDHB P07195 HTT Homo sapiens P42858
Y2H Pooling
32814053
Intra
LDHB P07195 HTT Homo sapiens P42858
Y2H Array
32814053
Intra
LDHB P07195 PEX5 Homo sapiens P50542
Validated Y2H
25416956
Intra
LDHB P07195 PEX5 Homo sapiens P50542
Y2H Array
25416956
Intra
LDHB P07195 TERF1 Homo sapiens P54274
BiFC
21044950
Intra
LDHB P07195 TERF1 Homo sapiens P54274
Pull Down
21044950
Intra
LDHB P07195 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
LDHB P07195 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LDHB Proteins

Cat. No. Product Name Accession Purity
HY-P70265 LDHB Protein, Human (His) P07195 (M1-L334) ≥ 95%, as determined by reducing SDS-PAGE.

LDHB Antibodies

Cat. No. Product Name Application Reactivity
HY-P82325 Lactate Dehydrogenase B Antibody (YA2070) WB, IHC-P, ICC/IF, IP, FC Human

Related Diseases

Diseases Alias
Lactate Dehydrogenase B Deficiency

  • LDHBD

  • Glycogen Storage Disease Due To Lactate Dehydrogenase H-Subunit Deficiency

  • Lactate Dehydrogenase-B Deficiency

  • Ldh Deficiency B

  • Lactate Dehydrogenase Deficiency Type B

  • Gsd Due To Lactate Dehydrogenase H-Subunit Deficiency

  • Glycogenosis Due To Lactate Dehydrogenase H-Subunit Deficiency

  • Ldh-H Subunit Deficiency
Maxillary Sinus Cancer

  • Malignant Neoplasm Of Antrum

  • Malignant Tumor Of The Maxillary Sinus

  • Maxillary Sinus Carcinoma

  • Cancer Of Maxillary Sinus

  • Maxillary Sinus Neoplasms
Maxillary Sinus Squamous Cell Carcinoma

  • Epidermoid Carcinoma Of The Maxillofacial Sinus
Retinitis Pigmentosa-Deafness Syndrome

  • Retinitis Pigmentosa 8, Formerly

  • Rp8, Formerly

  • Retinitis Pigmentosa 21, Formerly

  • Rp21, Formerly

  • Usher Syndrome
Alzheimer Disease 13

  • AD13

  • Alzheimer Disease-13

  • Alzheimer'S Disease 13

  • Alzheimer'S Disease 13, Late Onset
Parkinson Disease 17

  • PARK17

  • Parkinson'S Disease 17

  • Autosomal Dominant Parkinson Disease 17

  • Parkinson Disease, Type 17
Paranasal Sinus Cancer

  • Paranasal Sinus Adenoid Cystic Carcinoma

  • Paranasal Sinus Mucoepidermoid Carcinoma

  • Paranasal Sinus Squamous Cell Carcinoma

  • Paranasal Sinus Neoplasms

  • Adenoid Cystic Carcinoma Of Accessory Sinus

  • Adenoid Cystic Carcinoma Of Paranasal Sinus

  • Epidermoid Carcinoma Of The Paranasal Sinus

  • Mucoepidermoid Carcinoma Of Accessory Sinus

  • Paranasal Sinus Adenocarcinoma

  • Squamous Cell Carcinoma Of Paranasal Sinus

  • Paranasal Sinus Neoplasm

  • Adenocarcinoma Of Accessory Sinus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100742A (R)-GNE-140 Inhibitor 99.77% Unkown
HY-147216 AXKO-0046 Inhibitor 99.77% Unkown
HY-100742B (S)-GNE-140 Inhibitor 99.30% Unkown
HY-118241 GNE-140 Inhibitor 98.43% Unkown
HY-175562 LDH-IN-4 Inhibitor / Unkown
HY-183858 NCATS-SM1440 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus LDHB VGNC VGNC:30824
Mus musculus LDHB MGD MGI:96763
Rattus norvegicus LDHB RGD RGD:2997
Others LDHB NCBI