Mme - membrane metallo-endopeptidase Gene

Also Known as Nep; SFE; CD10

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24590

Summary

Enables oligopeptidase activity and peptide binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; animal organ development; and proteolysis. Located in plasma membrane. Used to study diarrhea and hypertension. Biomarker of Alzheimer's disease; congestive heart failure; and hepatocellular carcinoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Charcot-Marie-Tooth disease axonal type 2T; cerebellar ataxia type 43; cerebral amyloid angiopathy; and membranous glomerulonephritis. Orthologous to human MME (membrane metalloendopeptidase). [provided by Alliance of Genome Resources, Apr 2022]

Mme Products (1)

mRNA Protein Name
NM_012608.2 NP_036740.1 neprilysin

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables oligopeptidase activity IDA
IDA: Inferred from direct assay
3522576 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
15308303 RGD
Biological Process GO Annotation Evidence References Source
involved in amyloid-beta clearance IDA
IDA: Inferred from direct assay
19406747 RGD
involved in amyloid-beta clearance by cellular catabolic process IMP
IMP: Inferred from mutant phenotype
18941241 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
1547865 RGD
involved in lung development IEP
IEP: Inferred from expression pattern
1547865 RGD
involved in peptide metabolic process IMP
IMP: Inferred from mutant phenotype
10642323 RGD
involved in placenta development IEP
IEP: Inferred from expression pattern
1547865 RGD
involved in protein catabolic process IDA
IDA: Inferred from direct assay
15308303 RGD
involved in response to estrogen IDA
IDA: Inferred from direct assay
15308303 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neprilysin

  • atriopeptidase

  • enkephalinase

  • membrane metallo-endopeptidase (neutral endopeptidase/enkephalinase)

  • neutral endopeptidase 24.11

  • skin fibroblast elastase

Recombinant Mme Proteins

Cat. No. Product Name Accession Purity
HY-P73746 MME/Neprilysin Protein, Rat (HEK293, His) P07861 (Y52-W750) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-165037 1,2-Dimyristoyl-3-eicosapentaenoyl-rac-glycerol / Phase 3

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08513 MME Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08522 MMP12 Human Pre-designed siRNA Set A / Unkown
HY-RS08523 Mmp12 Mouse Pre-designed siRNA Set A / Unkown
HY-RS08524 Mmp12 Rat Pre-designed siRNA Set A / Unkown
HY-RS17321 Mme Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23776 Mme Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mme NCBI NCBI:4311