Pdgfrb - platelet derived growth factor receptor beta Gene

Rattus norvegicus

Also known as PDGFR-1

Gene ID: 24629 | Gene type: protein coding

About Pdgfrb

Primary_assembly 18: 54,499,964-54,538,843 forward strand.mRatBN7.2:CM026991.1

This gene has 3 transcripts (splice variants), 247 orthologues, 54 paralogues and is associated with 59 phenotypes. Biased expression in Kidney (RPKM 224.3), Lung (RPKM 214.5) and 9 other tissues.

Summary

Enables phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor-activated receptor activity. Involved in several processes, including animal organ development; positive regulation of Rho protein signal transduction; and regulation of apoptotic process. Located in several cellular components, including apical plasma membrane; cell surface; and nucleus. Used to study extrahepatic cholestasis; middle cerebral artery infarction; and prostate Cancer. Biomarker of hypertension; oligohydramnios; and sciatic neuropathy. Human ortholog(s) of this gene implicated in basal ganglia calcification; glioblastoma; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Orthologous to human PDGFRB (platelet derived growth factor receptor beta). [provided by Alliance of Genome Resources, Apr 2022]

Pdgfrb Products(1)

mRNA	Protein	Name
NM_031525.2	NP_113713.1	platelet-derived growth factor receptor beta precursor

Pdgfrb Protein Structure

PKc_like

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1097 a.a.

Protein Preferred Names

Protein Names

platelet-derived growth factor receptor beta

CD140 antigen-like family member B	PDGF-R-beta
PDGFR-beta	Platelet-derived growth factor receptor, beta
beta platelet-derived growth factor receptor	beta-type platelet-derived growth factor receptor
platelet derived growth factor receptor, beta polypeptide	platelet-derived growth factor receptor 1

Recombinant Pdgfrb Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73360	PDGF R beta Protein, Rat (HEK293, His)	Q05030 (L32-V531)	≥95%
HY-P74644	PDGF R beta Protein, Rat (HEK293, Fc)	Q05030 (L32-K530)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15813	FIIN-1	Inhibitor	99.11%	Unkown
HY-RS10257	PDGFRB Human Pre-designed siRNA Set A		/	Unkown
HY-RS10258	Pdgfrb Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS10259	Pdgfrb Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pdgfrb	NCBI	NCBI:5159
Canis familiaris	Pdgfrb	NCBI	NCBI:442985
Macaca mulatta	Pdgfrb	NCBI	NCBI:711353

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