Pfkfb2 - 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 Gene

Also Known as RH2K; PFK-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24640

Summary

Enables fructose-2,6-bisphosphate 2-phosphatase activity and kinase binding activity. Involved in several processes, including monocarboxylic acid metabolic process; positive regulation of Glucokinase activity; and positive regulation of Insulin secretion. Located in cytoplasm. Orthologous to human PFKFB2 (6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2). [provided by Alliance of Genome Resources, Apr 2022]

Pfkfb2 Products (3)

mRNA Protein Name
NM_001033964.2 NP_001029136.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform b
NM_001033965.2 NP_001029137.1 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform a
NM_080477.3 NP_536725.2 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables fructose-2,6-bisphosphate 2-phosphatase activity IDA
IDA: Inferred from direct assay
18039179 RGD
enables kinase binding IPI
IPI: Inferred from physical interaction
11522786 RGD
Biological Process GO Annotation Evidence References Source
involved in glucose catabolic process IDA
IDA: Inferred from direct assay
16980436 RGD
involved in lactate metabolic process IDA
IDA: Inferred from direct assay
16980436 RGD
involved in positive regulation of glucokinase activity IDA
IDA: Inferred from direct assay
16980436 RGD
involved in positive regulation of insulin secretion IDA
IDA: Inferred from direct assay
16980436 RGD
involved in pyruvate metabolic process IDA
IDA: Inferred from direct assay
16980436 RGD
involved in response to glucose IDA
IDA: Inferred from direct assay
16980436 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

  • 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (heart)

  • 6PF-2-K/Fru-2,6-P2ASE heart-type isozyme

  • 6PF-2-K/Fru-2,6-P2ase 2

  • PFK-2/FBPase-2

  • PFK/FBPase 2

  • fructose 6-phosphate 2-kinase/fructose 2,6-bisphosphatase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101972 AZ-PFKFB3-67 Inhibitor 97.03% Unkown
HY-101971 AZ PFKFB3 26 Inhibitor 99.23% Unkown
HY-101972A AZ-PFKFB3-67 quarterhydrate Inhibitor 99.0% Unkown
HY-184148 PFKFB3-IN-3 Inhibitor / Unkown
HY-RS10362 PFKFB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20188 Pfkfb2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26692 Pfkfb2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pfkfb2 NCBI NCBI:5208