Pklr - pyruvate kinase L/R Gene

Also Known as PK1; PKL; Pklg

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24651

Summary

Enables Pyruvate Kinase activity. Involved in several processes, including cellular response to organonitrogen compound; pyruvate metabolic process; and response to purine-containing compound. Located in cytosol. Biomarker of hyperglycemia. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; Pyruvate Kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (Pyruvate Kinase L/R). [provided by Alliance of Genome Resources, Apr 2022]

Pklr Products (1)

mRNA Protein Name
NM_012624.3 NP_036756.3 pyruvate kinase PKLR

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables monosaccharide binding IPI
IPI: Inferred from physical interaction
6742850 RGD
enables pyruvate kinase activity IDA
IDA: Inferred from direct assay
1834654 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to epinephrine stimulus IEP
IEP: Inferred from expression pattern
10620345 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
9395079 RGD
involved in glycolytic process IDA
IDA: Inferred from direct assay
4273555 RGD
involved in pyruvate biosynthetic process IDA
IDA: Inferred from direct assay
4273555 RGD
involved in response to ATP IDA
IDA: Inferred from direct assay
11104754 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
9395079 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
16644726 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
11356723 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
11357483 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
11368649 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pyruvate kinase PKLR

  • L-PK

  • pyruvate kinase isozymes L/R

  • pyruvate kinase isozymes R/L

  • pyruvate kinase, liver and RBC

  • pyruvate kinase, liver and red blood cell

Recombinant Pklr Proteins

Cat. No. Product Name Accession Purity
HY-P700578 PKLR Protein, Rat (P. pastoris, His) P12928 (M1-S574) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12689 Mitapivat Activator 99.84% Yes
HY-12689A Mitapivat hemisulfate sesquihydrate Activator / Unkown
HY-12689B Mitapivat hemisulfate Activator / Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-135884 Tebapivat Activator 99.66% Phase 2

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-122682 SBI-993 98.79% Unkown
HY-12689S Mitapivat-d8 Activator / Unkown
HY-RS10601 PKLR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18255 Pklr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24735 Pklr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pklr NCBI NCBI:5313