Pnmt - phenylethanolamine-N-methyltransferase Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24661

Summary

Enables phenylethanolamine N-methyltransferase activity. Involved in several processes, including Catecholamine metabolic process; cellular response to dexamethasone stimulus; and response to peptide hormone. Located in several cellular components, including axon; dendrite; and perikaryon. Biomarker of hypertension and hypoglycemia. Human ortholog(s) of this gene implicated in Alzheimer's disease; hypertension; and multiple sclerosis. Orthologous to human PNMT (phenylethanolamine N-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Pnmt Products (1)

mRNA Protein Name
NM_031526.1 NP_113714.1 phenylethanolamine N-methyltransferase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables phenylethanolamine N-methyltransferase activity IDA
IDA: Inferred from direct assay
683413 RGD
Biological Process GO Annotation Evidence References Source
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
16140489 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
15564339 RGD
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
16926281 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
16926281 RGD
involved in epinephrine biosynthetic process IDA
IDA: Inferred from direct assay
7914070 RGD
involved in norepinephrine metabolic process IDA
IDA: Inferred from direct assay
3945626 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
19120122 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
21382450 RGD
involved in response to ether IEP
IEP: Inferred from expression pattern
19120141 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
21046459 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
17683801 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
15677399 RGD
involved in response to isolation stress IEP
IEP: Inferred from expression pattern
20203532 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
15380299 RGD
involved in social behavior IEP
IEP: Inferred from expression pattern
15345906 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
19651110 RGD
located in dendrite IDA
IDA: Inferred from direct assay
20434498 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15869485 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
20434498 RGD
located in terminal bouton IDA
IDA: Inferred from direct assay
19651110 RGD
located in varicosity IDA
IDA: Inferred from direct assay
19651110 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phenylethanolamine N-methyltransferase

  • PNMTase

  • noradrenaline N-methyltransferase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-142110 LY 78335 Inhibitor 99.19% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pnmt NCBI NCBI:5409