Ppp3cb - protein phosphatase 3 catalytic subunit beta Gene

Also Known as Calna2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24675

Summary

Enables calcium-dependent protein serine/threonine Phosphatase activity and Calmodulin binding activity. Involved in several processes, including muscle cell cellular homeostasis; positive regulation of Insulin secretion involved in cellular response to glucose stimulus; and response to amphetamine. Located in plasma membrane. Part of protein-containing complex. Is active in synapse. Biomarker of schizophrenia. Human ortholog(s) of this gene implicated in aortic valve stenosis. Orthologous to human PPP3CB (protein Phosphatase 3 catalytic subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Ppp3cb Products (1)

mRNA Protein Name
NM_017042.2 NP_058738.1 serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables calcium-dependent protein serine/threonine phosphatase activity IDA
IDA: Inferred from direct assay
12135494 RGD
enables calmodulin binding IDA
IDA: Inferred from direct assay
12135494 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15120593 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
12135494 RGD
Biological Process GO Annotation Evidence References Source
involved in muscle cell cellular homeostasis IEP
IEP: Inferred from expression pattern
11997253 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
11978799 RGD
involved in protein dephosphorylation IDA
IDA: Inferred from direct assay
12135494 RGD
involved in regulation of insulin secretion IDA
IDA: Inferred from direct assay
11978799 RGD
involved in response to amphetamine IEP
IEP: Inferred from expression pattern
11954050 RGD
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
11978799 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16306226 RGD
is active in synapse IDA
IDA: Inferred from direct assay
1313851 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

  • CAM-PRP catalytic subunit

  • CNA beta

  • CaN Abeta

  • Calcineurin subunit A beta

  • protein phosphatase 3, catalytic subunit, beta isozyme

  • protein phosphatase-2Bb

Ppp3cb Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Ppp3cb P20651 Akap6 Rattus norvegicus Q9WVC7
Anti Tag CoIP
19883655
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11024 PPP3CB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppp3cb NCBI NCBI:5532