Akap6 - A-kinase anchoring protein 6 Gene

Also Known as mAkap

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64553

Summary

Enables several functions, including enzyme binding activity; protein kinase A regulatory subunit binding activity; and transmembrane transporter binding activity. Involved in several processes, including positive regulation of cellular protein metabolic process; regulation of intracellular signal transduction; and regulation of muscle system process. Located in several cellular components, including T-tubule; intercalated disc; and junctional sarcoplasmic reticulum membrane. Part of protein-containing complex. Colocalizes with nuclear envelope. Human ortholog(s) of this gene implicated in anorexia nervosa and ovary epithelial Cancer. Orthologous to human AKAP6 (A-kinase anchoring protein 6). [provided by Alliance of Genome Resources, Apr 2022]

Akap6 Products (1)

mRNA Protein Name
NM_022618.2 NP_072140.2 A-kinase anchor protein 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables adenylate cyclase binding IDA
IDA: Inferred from direct assay
19574217 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
15182229 RGD
enables molecular adaptor activity IDA
IDA: Inferred from direct assay
11590243 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15652351 RGD
enables protein kinase A binding IDA
IDA: Inferred from direct assay
10413680 RGD
enables protein kinase A regulatory subunit binding IDA
IDA: Inferred from direct assay
9679148 RGD
enables protein phosphatase 2A binding IDA
IDA: Inferred from direct assay
11590243 RGD
enables protein-membrane adaptor activity IDA
IDA: Inferred from direct assay
10413680 RGD
enables transmembrane transporter binding IDA
IDA: Inferred from direct assay
9679148 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
11590243 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to cytokine stimulus IMP
IMP: Inferred from mutant phenotype
16177794 RGD
involved in cellular response to epinephrine stimulus IMP
IMP: Inferred from mutant phenotype
11179196 RGD
involved in negative regulation of adenylate cyclase activity IMP
IMP: Inferred from mutant phenotype
19574217 RGD
involved in positive regulation of cAMP-dependent protein kinase activity IMP
IMP: Inferred from mutant phenotype
11179196 RGD
involved in positive regulation of calcineurin-NFAT signaling cascade IMP
IMP: Inferred from mutant phenotype
16306226 RGD
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
16177794 RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development IDA
IDA: Inferred from direct assay
16306226 RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development IMP
IMP: Inferred from mutant phenotype
21550986 RGD
involved in positive regulation of protein phosphorylation IMP
IMP: Inferred from mutant phenotype
11179196 RGD
involved in positive regulation of release of sequestered calcium ion into cytosol IMP
IMP: Inferred from mutant phenotype
12709444 RGD
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
16306226 RGD
involved in protein-containing complex localization IMP
IMP: Inferred from mutant phenotype
11179196 RGD
involved in regulation of cAMP/PKA signal transduction IDA
IDA: Inferred from direct assay
12709444 RGD
involved in regulation of cardiac muscle cell contraction IMP
IMP: Inferred from mutant phenotype
11179196 RGD
involved in regulation of relaxation of cardiac muscle IMP
IMP: Inferred from mutant phenotype
11179196 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
9679148 RGD
located in caveola IDA
IDA: Inferred from direct assay
20224290 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
9679148 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
9679148 RGD
located in junctional sarcoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
12709444 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
10413680 RGD
located in nuclear membrane IDA
IDA: Inferred from direct assay
10413680 RGD
located in nucleus IDA
IDA: Inferred from direct assay
9679148 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
11296225 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
11296225 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
9679148 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
7721854 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

A-kinase anchor protein 6

  • A kinase (PRKA) anchor protein 6

  • AKAP-6

  • PRKA6

  • protein kinase A-anchoring protein 6

Akap6 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Akap6 Q9WVC7 Ppp3cb Rattus norvegicus P20651
Anti Bait CoIP
19883655
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00521 AKAP6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22383 Akap6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28907 Akap6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akap6 NCBI NCBI:9472