Il27 - interleukin 27 Gene

Also Known as p28; Il30; IL-27; IL27-A; IL-27-A; IL-27p28

Species: Mus musculus

Gene Type: protein coding
Gene ID: 246779

Summary

Enables interleukin-27 receptor binding activity. Acts upstream of or within positive regulation of defense response to virus by host and regulation of T cell proliferation. Located in extracellular space. Is expressed in decidua; embryo; and extraembryonic component. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and pulmonary tuberculosis. Orthologous to human IL27 (interleukin 27). [provided by Alliance of Genome Resources, Apr 2022]

Il27 Products (1)

mRNA Protein Name
NM_145636.2 NP_663611.1 interleukin-27 subunit alpha precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables interleukin-27 receptor binding IDA
IDA: Inferred from direct assay
12121660 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12121660 MGI
enables signaling receptor binding IDA
IDA: Inferred from direct assay
12121660 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of defense response to virus by host IDA
IDA: Inferred from direct assay
25268627 MGI
acts upstream of or within positive regulation of defense response to virus by host IGI
IGI: Inferred from genetic interaction
25268627 MGI
acts upstream of or within regulation of T cell proliferation IDA
IDA: Inferred from direct assay
12121660 MGI
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
12121660 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-27 subunit alpha

  • IL-27 p28 subunit

  • IL-27 subunit alpha

  • interleukin 30

Recombinant Il27 Proteins

Cat. No. Product Name Accession Purity
HY-P72554 IL-27 Protein, Mouse (HEK293, His) O35228 (Y19-P228) & Q8K3I6 (F29-S234) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P700206AF Animal-Free IL-30/IL-27A Protein, Mouse (His) Q8K3I6 (F29-S234) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P990024 Casdozokitug Inhibitor 96.49% Phase 2

Pre-clinical Phase

Bioactive Molecules (11)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-151508 Diamino lipid DAL4 / Unkown
HY-RS06746 IL27 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06747 IL27RA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08889 MYDGF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174612 Human IL27RA mRNA / Unkown
HY-174613 Human IL27 mRNA / Unkown
HY-RS17022 Ebi3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17036 Il27 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20169 Il27ra Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23480 Il27 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26673 Il27ra Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990215 Anti-Mouse IL-27 p28 Antibody (MM27.7B1) Inhibitor 95.00% Unkown
HY-P992246 Anti-IL-27RA Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il27 NCBI NCBI:246778