Slc4a1 - solute carrier family 4 member 1 (Diego blood group) Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24779

Summary

Enables actin binding activity; enzyme binding activity; and protein C-terminus binding activity. Involved in several processes, including positive regulation of T cell proliferation; response to alkaline pH; and response to carbon dioxide. Located in several cellular components, including Z disc; basolateral plasma membrane; and intercalated disc. Biomarker of iron deficiency anemia; metabolic acidosis; and renal tubular acidosis. Human ortholog(s) of this gene implicated in congenital hemolytic anemia; hereditary spherocytosis; hereditary spherocytosis type 4; malaria; and renal tubular acidosis. Orthologous to human SLC4A1 (solute carrier family 4 member 1 (Diego blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Slc4a1 Products (1)

mRNA Protein Name
NM_012651.2 NP_036783.2 band 3 anion transport protein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IPI
IPI: Inferred from physical interaction
12898519 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
17652430 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
20946910 RGD
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
21903759 RGD
involved in positive regulation of T cell proliferation IDA
IDA: Inferred from direct assay
12165075 RGD
involved in response to acidic pH IEP
IEP: Inferred from expression pattern
10600930 RGD
involved in response to activity IDA
IDA: Inferred from direct assay
24289085 RGD
involved in response to alkaline pH IEP
IEP: Inferred from expression pattern
10600930 RGD
involved in response to arsenic-containing substance IDA
IDA: Inferred from direct assay
20946910 RGD
involved in response to carbon dioxide IDA
IDA: Inferred from direct assay
15075205 RGD
involved in response to hydrogen peroxide IDA
IDA: Inferred from direct assay
20946910 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
21903759 RGD
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
12898519 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
9596071 RGD
located in cell surface IDA
IDA: Inferred from direct assay
20114059 RGD
located in intercalated disc IDA
IDA: Inferred from direct assay
12898519 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

band 3 anion transport protein

  • AE 1

  • Solute carrier family 4, member 1, anion exchange protein 1 (kidney band 3)

  • anion exchange protein 1

  • anion exchanger 1

  • solute carrier family 4 (anion exchanger), member 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13265 SLC4A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20193 Slc4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26698 Slc4a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc4a1 NCBI NCBI:6521