Tph1 - tryptophan hydroxylase 1 Gene

Also Known as Tph

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24848

Summary

Enables tryptophan 5-monooxygenase activity. Involved in circadian rhythm; negative regulation of ossification; and response to immobilization stress. Located in neuron projection. Biomarker of mental depression. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; mental depression (multiple); and scoliosis. Orthologous to human TPH1 (Tryptophan Hydroxylase 1). [provided by Alliance of Genome Resources, Apr 2022]

Tph1 Products (1)

mRNA Protein Name
NM_001100634.3 NP_001094104.1 tryptophan 5-hydroxylase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables tryptophan 5-monooxygenase activity IDA
IDA: Inferred from direct assay
12354109 RGD
Biological Process GO Annotation Evidence References Source
involved in circadian rhythm IEP
IEP: Inferred from expression pattern
18705647 RGD
involved in negative regulation of ossification IMP
IMP: Inferred from mutant phenotype
20139991 RGD
involved in response to immobilization stress IEP
IEP: Inferred from expression pattern
14744469 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tryptophan 5-hydroxylase 1

  • tryptophan 5-monooxygenase 1

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-101124 Rodatristat ethyl Inhibitor 99.82% Phase 2
HY-120083 Rodatristat Inhibitor 98.41% Phase 2

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W019599 4-Chloro-L-phenylalanine Inhibitor 98.19% Unkown
HY-157014 TPT-004 Inhibitor 99.90% Unkown
HY-RS14932 TPH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-156093 TPH1-IN-1 Inhibitor / Unkown
HY-RS17127 Tph1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23572 Tph1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tph1 NCBI NCBI:7166