Slc6a3 - solute carrier family 6 member 3 Gene

Also Known as Dat1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24898

About Slc6a3

Primary_assembly 1: 29,709,443-29,750,413 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 166 orthologues, 20 paralogues and is associated with 31 phenotypes. Biased expression in Brain (RPKM 15.2), Kidney (RPKM .8) and 1 other tissue.

Summary

Enables several functions, including amine binding activity; dopamine:sodium symporter activity; and enzyme binding activity. Involved in several processes, including dopamine transport; response to cAMP; and response to ethanol. Located in neuron projection and plasma membrane. Is active in dopaminergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Biomarker of Parkinsonism; heroin dependence; high grade glioma; hyperprolactinemia; and hypertension. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder; nicotine dependence; and obesity. Orthologous to human SLC6A3 (solute carrier family 6 member 3). [provided by Alliance of Genome Resources, Apr 2022]

Slc6a3 Products (1)

mRNA Protein Name
NM_012694.2 NP_036826.1 sodium-dependent dopamine transporter

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables amine binding IDA
IDA: Inferred from direct assay
15763134 RGD
enables amine binding IPI
IPI: Inferred from physical interaction
15763134 RGD
enables dopamine:sodium symporter activity IDA
IDA: Inferred from direct assay
1765147 RGD
enables dopamine:sodium symporter activity IMP
IMP: Inferred from mutant phenotype
1502198 RGD
enables heterocyclic compound binding IPI
IPI: Inferred from physical interaction
15763134 RGD
enables norepinephrine:sodium symporter activity IDA
IDA: Inferred from direct assay
8125921 RGD
enables protease binding IPI
IPI: Inferred from physical interaction
19419578 RGD
enables protein phosphatase 2A binding IPI
IPI: Inferred from physical interaction
20035724 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
15056723 RGD
enables signaling receptor binding IPI
IPI: Inferred from physical interaction
18256931 RGD
Biological Process GO Annotation Evidence References Source
involved in dopamine transport IDA
IDA: Inferred from direct assay
1765147 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
15234104 RGD
involved in response to ethanol IDA
IDA: Inferred from direct assay
15897718 RGD
involved in response to iron ion IEP
IEP: Inferred from expression pattern
12672939 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
15157990 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
12541010 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15992364 RGD
Cellular Component GO Annotation Evidence References Source
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
8551328 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
32963038 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
21399631 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
8551328 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
8551328 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Slc6a3 Protein Structure

SLC6sbd_DAT1

SLC6sbd_DAT1: cd11514 (59 - 612)

  • 0
  • 100
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  • 500
  • 619 a.a.
Protein Preferred Names Protein Names

sodium-dependent dopamine transporter

  • DA transporter

  • DAT

  • solute carrier family 6 (neurotransmitter transporter), member 3

  • solute carrier family 6 (neurotransmitter transporter, dopamine), member 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13308 SLC6A3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13309 Slc6a3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13310 Slc6a3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc6a3 NCBI NCBI:6531