Slc22a1 - solute carrier family 22 member 1 Gene

Also Known as Oct1; Orct1; Roct1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24904

Summary

Enables several functions, including cation transmembrane transporter activity; identical protein binding activity; and toxin transmembrane transporter activity. Involved in several processes, including Catecholamine transport; ion transmembrane transport; and toxin transport. Located in apical plasma membrane and basolateral plasma membrane. Is integral component of plasma membrane. Used to study acute kidney failure. Biomarker of asthma; extrahepatic cholestasis; and intrahepatic cholestasis. Orthologous to human SLC22A1 (solute carrier family 22 member 1). [provided by Alliance of Genome Resources, Apr 2022]

Slc22a1 Products (1)

mRNA Protein Name
NM_012697.1 NP_036829.1 solute carrier family 22 member 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables acetylcholine transmembrane transporter activity IDA
IDA: Inferred from direct assay
15817714 RGD
enables dopamine:sodium symporter activity IDA
IDA: Inferred from direct assay
9776363 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
18361503 RGD
enables monoamine transmembrane transporter activity IDA
IDA: Inferred from direct assay
8955087 RGD
enables neurotransmitter transmembrane transporter activity IDA
IDA: Inferred from direct assay
15662044 RGD
enables norepinephrine:sodium symporter activity IDA
IDA: Inferred from direct assay
9776363 RGD
enables organic cation transmembrane transporter activity IDA
IDA: Inferred from direct assay
7990927 RGD
enables quaternary ammonium group transmembrane transporter activity IDA
IDA: Inferred from direct assay
8955087 RGD
enables toxin transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20477935 RGD
enables xenobiotic transmembrane transporter activity IDA
IDA: Inferred from direct assay
8955087 RGD
enables xenobiotic transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
20477935 RGD
Biological Process GO Annotation Evidence References Source
involved in acetylcholine transport IDA
IDA: Inferred from direct assay
15817714 RGD
involved in cellular detoxification IMP
IMP: Inferred from mutant phenotype
20477935 RGD
involved in dopamine transport IDA
IDA: Inferred from direct assay
9776363 RGD
involved in epinephrine transport IDA
IDA: Inferred from direct assay
9776363 RGD
involved in establishment or maintenance of transmembrane electrochemical gradient IDA
IDA: Inferred from direct assay
15817714 RGD
involved in metanephric proximal tubule development IEP
IEP: Inferred from expression pattern
30645697 RGD
involved in monoamine transport IDA
IDA: Inferred from direct assay
9776363 RGD
involved in monoatomic cation transmembrane transport IDA
IDA: Inferred from direct assay
7990927 RGD
involved in norepinephrine transport IDA
IDA: Inferred from direct assay
9776363 RGD
involved in organic cation transport IDA
IDA: Inferred from direct assay
7990927 RGD
involved in quaternary ammonium group transport IDA
IDA: Inferred from direct assay
9776363 RGD
involved in serotonin transport IDA
IDA: Inferred from direct assay
15662044 RGD
involved in xenobiotic transport IDA
IDA: Inferred from direct assay
8955087 RGD
involved in xenobiotic transport IMP
IMP: Inferred from mutant phenotype
20477935 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
15817714 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
7990927 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
12176030 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

solute carrier family 22 member 1

  • organic cation transporter 1

  • solute carrier family 22 (organic cation transporter), member 1

Slc22a1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Slc22a1 Q63089 Slc22a1 Rattus norvegicus Q63089
GMS
21896487
Intra
Slc22a1 Q63089 Slc22a1 Rattus norvegicus Q63089
FRET
21896487
Intra
Slc22a1 Q63089 oct1_oat1 Rattus norvegicus EBI-5261357
Pull Down
21896487
Intra
Slc22a1 Q63089 Slc22a1 Rattus norvegicus Q63089
Pull Down
21896487
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13061 SLC22A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19841 Slc22a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26339 Slc22a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc22a1 NCBI NCBI:6580