Nppb - natriuretic peptide B Gene

Also Known as BNP; Bnf

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25105

Summary

Enables hormone activity. Involved in several processes, including cellular response to mechanical stimulus; negative regulation of cell population proliferation; and positive regulation of cGMP-mediated signaling. Located in several cellular components, including extracellular space; perinuclear region of cytoplasm; and transport vesicle. Used to study hypertension; hypertensive heart disease; myocardial infarction; polycystic kidney disease; and proteinuria. Biomarker of several diseases, including artery disease (multiple); heart disease (multiple); hyperhomocysteinemia; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in atherosclerosis; hypertension; myocardial infarction; obesity; and systolic heart failure. Orthologous to human NPPB (natriuretic peptide B). [provided by Alliance of Genome Resources, Apr 2022]

Nppb Products (1)

mRNA Protein Name
NM_031545.1 NP_113733.1 natriuretic peptides B precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables hormone activity IDA
IDA: Inferred from direct assay
7552344 RGD
Biological Process GO Annotation Evidence References Source
involved in cell growth involved in cardiac muscle cell development IEP
IEP: Inferred from expression pattern
7657802 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
21812548 RGD
involved in heart development IEP
IEP: Inferred from expression pattern
8027030 RGD
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
17487460 RGD
involved in negative regulation of cholangiocyte proliferation IDA
IDA: Inferred from direct assay
28416225 RGD
involved in negative regulation of smooth muscle cell proliferation IDA
IDA: Inferred from direct assay
19104909 RGD
involved in negative regulation of systemic arterial blood pressure IDA
IDA: Inferred from direct assay
8289999 RGD
involved in positive regulation of cGMP-mediated signaling IDA
IDA: Inferred from direct assay
7552344 RGD
involved in positive regulation of collecting lymphatic vessel constriction IDA
IDA: Inferred from direct assay
23897233 RGD
involved in positive regulation of urine volume IDA
IDA: Inferred from direct assay
8289999 RGD
involved in response to 3-methylcholanthrene IEP
IEP: Inferred from expression pattern
19889059 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
17332063 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
17822384 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
22224641 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
33310031 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
17673002 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
17919123 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17767048 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
17332063 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16270351 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

natriuretic peptides B

  • Brain natriuretic factor

  • brain natriuretic factor prohormone

  • brain natriuretic peptide

  • gamma-brain natriuretic peptide

  • iso-ANP

  • natriuretic peptide precursor B

  • natriuretic peptide precursor type B

  • preproBNP

  • proBNP

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-101012 NPPB Inhibitor 99.78% Unkown
HY-153392 TYA-018 Inhibitor 99.84% Unkown
HY-RS09495 NPPB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-180583 GRK5-IN-5 Inhibitor / Unkown
HY-RS16787 Nppb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23227 Nppb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nppb NCBI NCBI:4879