Ncl - nucleolin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25135

Summary

Enables several functions, including ErbB-4 class receptor binding activity; laminin binding activity; and nucleic acid binding activity. Involved in several processes, including cellular response to lipopolysaccharide; liver regeneration; and positive regulation of cytokine production. Located in cell surface; cytoplasm; and nucleolus. Orthologous to human NCL (nucleolin). [provided by Alliance of Genome Resources, Apr 2022]

Ncl Products (1)

mRNA Protein Name
NM_012749.2 NP_036881.2 nucleolin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ErbB-4 class receptor binding IPI
IPI: Inferred from physical interaction
18523588 RGD
enables RNA binding IDA
IDA: Inferred from direct assay
2049089 RGD
enables calcium ion binding IDA
IDA: Inferred from direct assay
11948683 RGD
enables histone binding IDA
IDA: Inferred from direct assay
8424749 RGD
enables laminin binding IDA
IDA: Inferred from direct assay
8583499 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16854843 RGD
enables rRNA primary transcript binding IDA
IDA: Inferred from direct assay
3790520 RGD
enables selenocysteine insertion sequence binding IDA
IDA: Inferred from direct assay
20385601 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
6311246 RGD
enables signaling receptor binding IDA
IDA: Inferred from direct assay
18523588 RGD
enables single-stranded DNA binding IDA
IDA: Inferred from direct assay
6311246 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
21309751 RGD
involved in endocytosis IMP
IMP: Inferred from mutant phenotype
21309751 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
7490256 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20050922 RGD
involved in positive regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
21309751 RGD
involved in positive regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
21309751 RGD
involved in regulation of rRNA processing IDA
IDA: Inferred from direct assay
2049089 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
19570216 RGD
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
23912744 RGD
located in dense fibrillar component IDA
IDA: Inferred from direct assay
6206987 RGD
located in fibrillar center IDA
IDA: Inferred from direct assay
6206987 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleolin

  • nucleolin-like protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-174346 Skp2-IN-4 98.60% Unkown
HY-12645 NCL1 Inhibitor / Unkown
HY-178048 Neuroprotective agent 13 Activator / Unkown
HY-178052 Neuroprotective agent 14 Activator / Unkown
HY-RS03886 DNAJC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09086 NCL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-P5551 TLN-58 Inhibitor / Unkown
HY-RS17936 Ncl Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24407 Ncl Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncl NCBI NCBI:4691