Esr2 - estrogen receptor 2 Gene

Also Known as Erb2; ERbeta; ER-beta

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25149

About Esr2

Primary_assembly 6: 94,809,547-94,908,919 reverse strand.mRatBN7.2:CM026979.1

This gene has 4 transcripts (splice variants), 277 orthologues, 8 paralogues and is associated with 103 phenotypes. Biased expression in Uterus (RPKM 6.7), Brain (RPKM 3.1) and 5 other tissues.

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; estrogen binding activity; and steroid binding activity. Involved in several processes, including animal organ development; regulation of neuron death; and response to steroid hormone. Located in several cellular components, including mitochondrion; perikaryon; and perinuclear region of cytoplasm. Part of protein-DNA complex. Used to study several diseases, including hypertension (multiple); obesity; peritonitis; prostate carcinoma in situ; and transient cerebral ischemia. Biomarker of asthma; brain ischemia; colitis; cystitis; and osteoporosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); hypospadias; neurodegenerative disease (multiple); and ovarian dysgenesis 8. Orthologous to human ESR2 (Estrogen receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Esr2 Products (1)

mRNA Protein Name
NM_012754.3 NP_036886.3 estrogen receptor beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
12047722 RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12047722 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
19683557 RGD
enables estradiol binding IPI
IPI: Inferred from physical interaction
9292936 RGD
enables estrogen binding IPI
IPI: Inferred from physical interaction
9048584 RGD
enables estrogen response element binding IDA
IDA: Inferred from direct assay
9600083 RGD
enables heterocyclic compound binding IPI
IPI: Inferred from physical interaction
9048584 RGD
enables hormone binding IDA
IDA: Inferred from direct assay
17928626 RGD
enables hormone binding IMP
IMP: Inferred from mutant phenotype
15105439 RGD
enables hormone binding IPI
IPI: Inferred from physical interaction
9048584 RGD
enables nuclear steroid receptor activity IDA
IDA: Inferred from direct assay
17928626 RGD
enables organic cyclic compound binding IPI
IPI: Inferred from physical interaction
9048584 RGD
enables peroxisome proliferator activated receptor binding IPI
IPI: Inferred from physical interaction
20689342 RGD
enables promoter-specific chromatin binding IDA
IDA: Inferred from direct assay
24046281 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16020483 RGD
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12200235 RGD
enables steroid binding IDA
IDA: Inferred from direct assay
15705806 RGD
enables steroid hormone binding IPI
IPI: Inferred from physical interaction
9048584 RGD
Biological Process GO Annotation Evidence References Source
involved in Sertoli cell development IEP
IEP: Inferred from expression pattern
24056172 RGD
involved in Sertoli cell proliferation IMP
IMP: Inferred from mutant phenotype
17928626 RGD
involved in amygdala development IEP
IEP: Inferred from expression pattern
22791648 RGD
involved in behavioral fear response IDA
IDA: Inferred from direct assay
15514081 RGD
involved in cellular response to estradiol stimulus IEP
IEP: Inferred from expression pattern
17928626 RGD
involved in cellular response to lipopolysaccharide IMP
IMP: Inferred from mutant phenotype
21127968 RGD
involved in cellular response to magnetism IEP
IEP: Inferred from expression pattern
23469792 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
23596885 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
19279558 RGD
involved in cerebellum development IEP
IEP: Inferred from expression pattern
16542644 RGD
involved in estrous cycle IMP
IMP: Inferred from mutant phenotype
11854469 RGD
involved in female gonad development IEP
IEP: Inferred from expression pattern
9927330 RGD
involved in hypothalamus development IEP
IEP: Inferred from expression pattern
12960049 RGD
involved in learning or memory IMP
IMP: Inferred from mutant phenotype
16904920 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
15944240 RGD
involved in negative regulation of behavior IDA
IDA: Inferred from direct assay
15514081 RGD
involved in negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
12370428 RGD
involved in negative regulation of feeding behavior IMP
IMP: Inferred from mutant phenotype
12119576 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
15126114 RGD
involved in negative regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
23608653 RGD
involved in negative regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
22099601 RGD
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
9600083 RGD
involved in nuclear receptor-mediated steroid hormone signaling pathway IDA
IDA: Inferred from direct assay
17928626 RGD
involved in ovarian follicle development IEP
IEP: Inferred from expression pattern
17971845 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
15564578 RGD
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
17928626 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
24440742 RGD
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
22025007 RGD
involved in positive regulation of epidermal growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17928626 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
12047722 RGD
involved in prostate gland development IEP
IEP: Inferred from expression pattern
9492016 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
18516675 RGD
involved in response to bisphenol A IEP
IEP: Inferred from expression pattern
22957036 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
15087431 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19948032 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
15667451 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
23591044 RGD
involved in response to genistein IEP
IEP: Inferred from expression pattern
19230619 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
23591044 RGD
involved in response to human chorionic gonadotropin IEP
IEP: Inferred from expression pattern
10342845 RGD
involved in response to insecticide IEP
IEP: Inferred from expression pattern
23943137 RGD
involved in response to nicotine IEP
IEP: Inferred from expression pattern
27602328 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
18596125 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
24070737 RGD
involved in response to salt IEP
IEP: Inferred from expression pattern
12764114 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
23500659 RGD
involved in response to testosterone IMP
IMP: Inferred from mutant phenotype
16904920 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20686183 RGD
involved in vasodilation IMP
IMP: Inferred from mutant phenotype
24440742 RGD
Cellular Component GO Annotation Evidence References Source
located in mitochondrion IDA
IDA: Inferred from direct assay
15024130 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
23701910 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
16122717 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17928626 RGD
part of protein-DNA complex IDA
IDA: Inferred from direct assay
10342845 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Esr2 Protein Structure

ERbeta_N

ERbeta_N: pfam12497 (34 - 143)

NR_DBD_ER

NR_DBD_ER: cd07171 (162 - 243)

NR_LBD_ER

NR_LBD_ER: cd06949 (281 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 567 a.a.
Protein Preferred Names Protein Names

estrogen receptor beta

  • estrogen receptor 2 (ER beta)

  • estrogen receptor 2 beta

  • nuclear receptor subfamily 3 group A member 2

Esr2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Esr2 Q62986 Rps27a Rattus norvegicus P62989
Anti Bait CoIP
21808025
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-169063 ZINC05925939 Inhibitor / Unkown
HY-RS04532 ESR2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04533 Esr2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS04534 Esr2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Esr2 NCBI NCBI:2100