Pcsk1 - proprotein convertase subtilisin/kexin type 1 Gene

Also Known as BDP; PC1; PC3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25204

Summary

Enables endopeptidase activity. Involved in several processes, including nervous system development; protein processing; and response to morphine. Located in several cellular components, including perikaryon; rough endoplasmic reticulum; and trans-Golgi network. Colocalizes with secretory granule. Used to study hyperglycemia and type 2 diabetes mellitus. Biomarker of glucose metabolism disease (multiple); hyperthyroidism; hypothyroidism; islet cell tumor; and visual epilepsy. Human ortholog(s) of this gene implicated in obesity and proprotein convertase 1/3 deficiency. Orthologous to human PCSK1 (proprotein convertase subtilisin/kexin type 1). [provided by Alliance of Genome Resources, Apr 2022]

Pcsk1 Products (1)

mRNA Protein Name
NM_017091.2 NP_058787.1 neuroendocrine convertase 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables endopeptidase activity IDA
IDA: Inferred from direct assay
10087454 RGD
enables endopeptidase activity IMP
IMP: Inferred from mutant phenotype
9556596 RGD
Biological Process GO Annotation Evidence References Source
involved in neurogenesis IEP
IEP: Inferred from expression pattern
18781386 RGD
involved in pancreas development IEP
IEP: Inferred from expression pattern
17221210 RGD
involved in peptide hormone processing IDA
IDA: Inferred from direct assay
10087454 RGD
involved in peptide hormone processing IMP
IMP: Inferred from mutant phenotype
16497799 RGD
involved in pituitary gland development IEP
IEP: Inferred from expression pattern
15208361 RGD
involved in positive regulation of protein secretion IDA
IDA: Inferred from direct assay
9389490 RGD
involved in positive regulation of protein secretion IMP
IMP: Inferred from mutant phenotype
12721373 RGD
involved in protein autoprocessing IMP
IMP: Inferred from mutant phenotype
9556596 RGD
involved in protein processing IMP
IMP: Inferred from mutant phenotype
16497799 RGD
involved in response to axon injury IEP
IEP: Inferred from expression pattern
18585435 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
9556596 RGD
involved in response to chlorate IEP
IEP: Inferred from expression pattern
17221210 RGD
involved in response to fatty acid IEP
IEP: Inferred from expression pattern
18781386 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
11751617 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
17283238 RGD
involved in response to interleukin-1 IEP
IEP: Inferred from expression pattern
17283238 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
10630414 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
17584972 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
10971617 RGD
involved in response to peptide hormone IEP
IEP: Inferred from expression pattern
17584972 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
10971617 RGD
Cellular Component GO Annotation Evidence References Source
located in axon terminus IDA
IDA: Inferred from direct assay
10906712 RGD
located in dendrite IDA
IDA: Inferred from direct assay
10906712 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
9389490 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10906712 RGD
located in perikaryon IDA
IDA: Inferred from direct assay
17543468 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9389490 RGD
located in secretory granule IDA
IDA: Inferred from direct assay
7822759 RGD
located in trans-Golgi network IDA
IDA: Inferred from direct assay
10906712 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

neuroendocrine convertase 1

  • NEC 1

  • Protein convertase subtilisin / kexin, type I

  • prohormone convertase 1

  • prohormone convertase 3

  • proprotein convertase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10170 PCSK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10171 PCSK1N Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18538 Pcsk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25020 Pcsk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pcsk1 NCBI NCBI:5122