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P2ry1 - purinergic receptor P2Y1 Gene

Also Known as P2y; P2y1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25265

About P2ry1

Primary_assembly 2: 145,241,849-145,248,457 forward strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 191 orthologues, 13 paralogues and is associated with 3 phenotypes. Biased expression in Muscle (RPKM 119.4), Spleen (RPKM 41.7) and 8 other tissues.

Summary

Enables several functions, including A1 Adenosine Receptor binding activity; G protein-coupled purinergic nucleotide receptor activity; and adenyl ribonucleotide binding activity. Involved in several processes, including purinergic nucleotide receptor signaling pathway; regulation of cytosolic calcium ion concentration; and regulation of secretion by cell. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and postsynaptic density. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Colocalizes with mitochondrion. Used to study impotence. Orthologous to human P2RY1 (purinergic receptor P2Y1). [provided by Alliance of Genome Resources, Apr 2022]

P2ry1 Products (1)

mRNA	Protein	Name
NM_012800.3	NP_036932.1	P2Y purinoceptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables A1 adenosine receptor binding	IPI IPI: Inferred from physical interaction	11390975	RGD
enables ADP binding	IDA IDA: Inferred from direct assay	15152027	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	11557527	RGD
enables G protein-coupled ADP receptor activity	IDA IDA: Inferred from direct assay	20847060	RGD
enables G protein-coupled ATP receptor activity	IDA IDA: Inferred from direct assay	20847060	RGD
enables G protein-coupled purinergic nucleotide receptor activity	IDA IDA: Inferred from direct assay	15152027	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	11390975	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	20847060	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled adenosine receptor signaling pathway	IDA IDA: Inferred from direct assay	20847060	RGD
involved in G protein-coupled purinergic nucleotide receptor signaling pathway	IDA IDA: Inferred from direct assay	20847060	RGD
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15152027	RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11390975	RGD
involved in blood vessel diameter maintenance	IMP IMP: Inferred from mutant phenotype	12730558	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	17067301	RGD
involved in glial cell migration	IMP IMP: Inferred from mutant phenotype	20681951	RGD
NOT involved in microglial cell activation	IMP IMP: Inferred from mutant phenotype	11245682	RGD
involved in negative regulation of norepinephrine secretion	IDA IDA: Inferred from direct assay	19447154	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IDA IDA: Inferred from direct assay	20847060	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	20847060	RGD
involved in positive regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	19373936	RGD
involved in positive regulation of hormone secretion	IDA IDA: Inferred from direct assay	19515986	RGD
involved in positive regulation of inositol trisphosphate biosynthetic process	IDA IDA: Inferred from direct assay	11390975	RGD
involved in positive regulation of penile erection	IDA IDA: Inferred from direct assay	19303093	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20847060	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20847060	RGD
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	20847060	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	EXP EXP: Inferred from Experiment	16000618	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	16000618	RGD
involved in regulation of presynaptic cytosolic calcium ion concentration	IEP IEP: Inferred from expression pattern	16000618	RGD
involved in regulation of signaling receptor activity	IDA IDA: Inferred from direct assay	11390975	RGD
involved in regulation of synaptic vesicle exocytosis	EXP EXP: Inferred from Experiment	16000618	RGD
involved in regulation of synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	16000618	RGD
involved in regulation of synaptic vesicle exocytosis	IEP IEP: Inferred from expression pattern	16000618	RGD
involved in response to growth factor	IEP IEP: Inferred from expression pattern	14714568	RGD
involved in response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	14689471	RGD
involved in signal transduction involved in regulation of gene expression	IDA IDA: Inferred from direct assay	20847060	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11557527	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11557527	RGD
located in cell body	IDA IDA: Inferred from direct assay	12417330	RGD
located in dendrite	IDA IDA: Inferred from direct assay	12417330	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	16000618	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16000618	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	20847060	RGD
located in postsynaptic density	IDA IDA: Inferred from direct assay	20847060	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	20847060	RGD
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	16000618	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2ry1 Protein Structure

7tmA_P2Y1

0
100
200
300
373 a.a.

Protein Preferred Names	Protein Names
P2Y purinoceptor 1	ATP receptor P2 purinoreceptor subclass 2Y P2Y ATP receptor 1 purinergic receptor P2Y, G-protein coupled, 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS09914	P2RY1 Human Pre-designed siRNA Set A	/	Unkown
HY-RS09915	P2ry1 Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS09916	P2ry1 Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2ry1	NCBI	NCBI:5028