P2RY1 - purinergic receptor P2Y1 Gene

Also Known as P2Y1; SARCC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5028

About P2RY1

Cytogenetic location: 3q25.2 Genomic coordinates (GRCh38): 3:152,835,131-152,841,439 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues and 15 paralogues.

Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of Phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]

P2RY1 Products (1)

mRNA Protein Name
NM_002563.5 NP_002554.1 P2Y purinoceptor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IMP
IMP: Inferred from mutant phenotype
25822790 GOA
enables G protein-coupled ADP receptor activity IMP
IMP: Inferred from mutant phenotype
9442040 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9671706 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to purine-containing compound IMP
IMP: Inferred from mutant phenotype
9442040 GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9442040 GOA
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
9442040 GOA
Cellular Component GO Annotation Evidence References Source
located in cilium IDA
IDA: Inferred from direct assay
28154160 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
25822790 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RY1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (68 - 324)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
Protein Preferred Names Protein Names

P2Y purinoceptor 1

  • ADP receptor

  • ATP receptor

  • P2 purinoceptor subtype Y1

  • platelet ADP receptor

  • purinergic receptor P2Y, G-protein coupled, 1

  • suppressing androgen receptor in renal cell carcinoma

P2RY1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
P2RY1 P47900 NHERF1 Homo sapiens O14745
Filter Binding
9671706
Cross: Cross-species interaction Intra: Intraspecies interaction

P2RY1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810141 P2Y1 Antibody (YA9485) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat
HY-P84343 P2RY1 Antibody (YA4040) WB, IHC-P, FC, ELISA Human, Rat
HY-P84343A P2RY1 Antibody (YA4040)(PBS only) WB, IHC-P, FC, ELISA Human, Rat

Related Diseases

Diseases Alias
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Thrombosis

  • Thrombosis Of Blood Vessel
Infiltrative Basal Cell Carcinoma

  • Skin Infiltrating Basal Cell Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09914 P2RY1 Human Pre-designed siRNA Set A / Unkown
HY-RS09915 P2ry1 Mouse Pre-designed siRNA Set A / Unkown
HY-RS09916 P2ry1 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus P2RY1 RGD RGD:3242
Bos taurus P2RY1 VGNC VGNC:32523
Canis familiaris P2RY1 VGNC VGNC:44213
Macaca mulatta P2RY1 VGNC VGNC:75737
Felis catus P2RY1 VGNC VGNC:68673
Mus musculus P2RY1 MGD MGI:105049
Others P2RY1 NCBI