Mat1a - methionine adenosyltransferase 1A Gene

Also Known as SAS; SADE; AdoMet

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25331

Summary

Enables several functions, including adenyl ribonucleotide binding activity; magnesium ion binding activity; and methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and protein-containing complex assembly. Located in cytosol and nuclear matrix. Human ortholog(s) of this gene implicated in hypermethioninemia. Orthologous to human MAT1A (methionine adenosyltransferase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Mat1a Products (1)

mRNA Protein Name
NM_012860.2 NP_036992.2 S-adenosylmethionine synthase isoform type-1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ADP binding IDA
IDA: Inferred from direct assay
12888348 RGD
enables ATP binding IDA
IDA: Inferred from direct assay
10873471 RGD
enables amino acid binding IDA
IDA: Inferred from direct assay
10873471 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
9202427 RGD
enables magnesium ion binding IDA
IDA: Inferred from direct assay
12888348 RGD
enables methionine adenosyltransferase activity IDA
IDA: Inferred from direct assay
9202427 RGD
Biological Process GO Annotation Evidence References Source
involved in S-adenosylmethionine biosynthetic process IDA
IDA: Inferred from direct assay
9202427 RGD
involved in protein-containing complex assembly IDA
IDA: Inferred from direct assay
9202427 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear matrix IDA
IDA: Inferred from direct assay
19497982 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

S-adenosylmethionine synthase isoform type-1

  • MAT 1

  • MAT-I/III

  • S - adenosylmethionine synthetase

  • adoMet synthase 1

  • adoMet synthetase 1

  • methionine adenosyltransferase 1

  • methionine adenosyltransferase I, alpha

  • methionine adenosyltransferase I/III

Mat1a Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Mat1a P13444 Mat1a Rattus norvegicus P13444
Reverse Phase Chrom
9202427
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-116688 2-Hydroxy-4-(methylthio)butyric acid 88.0% Unkown
HY-162353 AZ'9567 99.19% Unkown
HY-RS08166 MAT1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20986 Mat1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27503 Mat1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mat1a NCBI NCBI:4143