LYG2 - lysozyme g2 Gene

Also Known as LYGH; LYGA2; LYSG2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 254773

About LYG2

Cytogenetic location: 2q11.2 Genomic coordinates (GRCh38): 2:99,242,246-99,261,522 (from NCBI)

This gene has 5 transcripts (splice variants), 337 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

The protein encoded by this gene contains a SLT domain, a protein domain present in Bacterial lytic transglycosylase (SLT) and in eukaryotic lysozymes (GEWL). SLT domain catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetyglucosamine (GlcNAc). [provided by RefSeq, Jul 2008]

LYG2 Products (1)

mRNA Protein Name
NM_175735.4 NP_783862.2 lysozyme g-like protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lysozyme activity IDA
IDA: Inferred from direct assay
21093056 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in defense response to Gram-positive bacterium IDA
IDA: Inferred from direct assay
21093056 GOA
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
21093056 GOA
Cellular Component GO Annotation Evidence References Source
located in extracellular region IDA
IDA: Inferred from direct assay
21093056 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LYG2 Protein Structure

SLT

SLT: Transglycosylase SLT domain (83 - 183)

  • 0
  • 100
  • 200
  • 212 a.a.
Protein Preferred Names Protein Names

lysozyme g-like protein 2

  • lysozyme G-like 2

LYG2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LYG2 Q86SG7 TEPSIN Homo sapiens Q96N21
Validated Y2H
32296183
Intra
LYG2 Q86SG7 TEPSIN Homo sapiens Q96N21
Y2H Array
32296183
Intra
LYG2 Q86SG7 TEPSIN Homo sapiens Q96N21
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LYG2 Proteins

Cat. No. Product Name Accession Purity
HY-P70868 LYG2 Protein, Human (HEK293, His) Q86SG7-1 (S20-F212) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07911 LYG2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22227 Lyg2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28749 Lyg2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LYG2 VGNC VGNC:42881
Macaca mulatta LYG2 VGNC VGNC:74398
Felis catus LYG2 VGNC VGNC:63338
Mus musculus LYG2 MGD MGI:2685622
Bos taurus LYG2 VGNC VGNC:31096
Rattus norvegicus LYG2 RGD RGD:6496811
Others LYG2 NCBI