Nog - noggin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25495

Summary

Predicted to enable cytokine binding activity and protein homodimerization activity. Involved in several processes, including hippocampus development; learning or memory; and regulation of gliogenesis. Located in axon and extracellular space. Part of protein-containing complex. Biomarker of acute kidney tubular necrosis and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Huntington's disease; cleft lip; dysostosis (multiple); hyperopia; and proximal symphalangism (multiple). Orthologous to human NOG (noggin). [provided by Alliance of Genome Resources, Apr 2022]

Nog Products (1)

mRNA Protein Name
NM_012990.1 NP_037122.1 noggin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15199066 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
15199066 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to BMP stimulus IEP
IEP: Inferred from expression pattern
21238590 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
25740156 RGD
involved in forebrain development IEP
IEP: Inferred from expression pattern
14643011 RGD
involved in hippocampus development IEP
IEP: Inferred from expression pattern
15171992 RGD
involved in memory IMP
IMP: Inferred from mutant phenotype
12740172 RGD
involved in mesenchymal cell differentiation IMP
IMP: Inferred from mutant phenotype
21238590 RGD
involved in negative regulation of astrocyte differentiation IMP
IMP: Inferred from mutant phenotype
14975730 RGD
involved in ossification IEP
IEP: Inferred from expression pattern
24611347 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15265600 RGD
involved in positive regulation of oligodendrocyte progenitor proliferation IMP
IMP: Inferred from mutant phenotype
14975730 RGD
involved in visual learning IMP
IMP: Inferred from mutant phenotype
12740172 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
21447372 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
15199066 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15199066 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

noggin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Phase
HY-P99618 Fidasimtamab Inhibitor 95.00% Phase 2
HY-P99836 Cudarolimab Inhibitor 95.00% Phase 1
HY-P991587 SAR-446523 Inhibitor / Phase 1

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-164899 2A3 99.92% Unkown
HY-163532 FLS-359 Modulator 95.41% Unkown
HY-170452 MDM2 ligand 4 Ligand / Unkown
HY-175236 SF-9-2 / Unkown
HY-RS09410 NOG Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17067 Nog Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23511 Nog Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992381 IBI352g4a / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nog NCBI NCBI:9241
Canis familiaris Nog NCBI NCBI:100683515
Macaca fascicularis Nog NCBI NCBI:102145726
Mus musculus Nog NCBI NCBI:18121
Leporidae Nog NCBI
Macaca mulatta Nog NCBI NCBI:707338