Npm1 - nucleophosmin 1 Gene

Also Known as B23NP

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25498

Summary

Enables several functions, including anion binding activity; p53 binding activity; and protein kinase B binding activity. Involved in several processes, including RNA metabolic process; negative regulation of apoptotic process; and regulation of DNA replication. Located in cytoplasm and nuclear lumen. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1). [provided by Alliance of Genome Resources, Apr 2022]

Npm1 Products (1)

mRNA Protein Name
NM_012992.4 NP_037124.1 nucleophosmin

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ATP binding IMP
IMP: Inferred from mutant phenotype
19123973 RGD
enables DNA binding IDA
IDA: Inferred from direct assay
8611572 RGD
enables enzyme binding IDA
IDA: Inferred from direct assay
11481036 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
15893727 RGD
enables identical protein binding IPI
IPI: Inferred from physical interaction
8611572 RGD
enables p53 binding IPI
IPI: Inferred from physical interaction
15872011 RGD
enables phosphatidylinositol-3,4,5-trisphosphate binding IPI
IPI: Inferred from physical interaction
15893727 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10220582 RGD
enables protein kinase B binding IDA
IDA: Inferred from direct assay
18931307 RGD
Biological Process GO Annotation Evidence References Source
involved in cardiac muscle hypertrophy IEP
IEP: Inferred from expression pattern
21444791 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
21444791 RGD
involved in cellular response to testosterone stimulus IEP
IEP: Inferred from expression pattern
8287071 RGD
involved in cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IDA
IDA: Inferred from direct assay
9742256 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
14635188 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
21444791 RGD
involved in negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
15872011 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
19123973 RGD
involved in positive regulation of DNA metabolic process IDA
IDA: Inferred from direct assay
11481036 RGD
involved in positive regulation of DNA replication IDA
IDA: Inferred from direct assay
11481036 RGD
involved in positive regulation of DNA-directed DNA polymerase activity IDA
IDA: Inferred from direct assay
8123045 RGD
involved in positive regulation of catalytic activity IDA
IDA: Inferred from direct assay
11481036 RGD
involved in rRNA transcription IMP
IMP: Inferred from mutant phenotype
21444791 RGD
involved in regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
15893727 RGD
Cellular Component GO Annotation Evidence References Source
located in nuclear matrix IDA
IDA: Inferred from direct assay
20387789 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
14635188 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nucleophosmin

  • NPM

  • nucleolar phosphoprotein B23

  • nucleolar protein B23.1

  • nucleolar protein NO38

  • nucleophosmin (nucleolar phosphoprotein B23, numatrin)

  • numatrin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-156794 Enzomenib Inhibitor 99.88% Unkown
HY-136360 MI-3454 Inhibitor 98.03% Unkown
HY-162350 TDI-11055 98.18% Unkown
HY-162265A UCM-13369 dihydrochloride Inducer 99.87% Unkown
HY-172416 Balomenib Inhibitor 99.81% Unkown
HY-N10264 Avrainvillamide 95.08% Unkown
HY-164279 YTR107 95.33% Unkown
HY-156794A Enzomenib enantiomer Inhibitor 98.01% Unkown
HY-162265 UCM-13369 Inducer / Unkown
HY-114162B VTP50469 mesylate / Unkown
HY-122670 VS-II-173 / Unkown
HY-181690 Menin-MLL-IN-37 Inhibitor / Unkown
HY-208723 MAP3K1-IN-1 Inhibitor / Unkown
HY-E70760 NPM1 ALK Recombinant Human Active Protein Kinase / Unkown
HY-E70761 NPM1 ALK F1174L Recombinant Human Active Protein Kinase / Unkown
HY-RS09490 NPM1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17071 Npm1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18762 Gja1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23515 Npm1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Npm1 NCBI NCBI:4869