Menin-MLL-IN-37
Menin-MLL-IN-37 is an orally active Menin-MLL protein complex inhibitor with an IC50 of 820.50 nM. Menin-MLL-IN-37 disrupts the interaction between menin and MLL proteins. Menin-MLL-IN-37 induces differentiation of acute myeloid leukemia cells and selectively inhibits the proliferation of MLL-rearranged and DNMT3A/NPM1-mutant leukemia cells. Menin-MLL-IN-37 can be used for the research of acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- Formula: C29H37F3N6O3S2
- Molecular Weight:638.77
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Menin-MLL 820.50 nM (IC50) |
Menin-MLL-IN-37 (Compound A13) potently inhibits the proliferation of MLL-rearranged (MV4-11, MOLM-13), DNMT3A/NPM1-mutated (OCI-AML3) and other leukemia cell lines (THP-1, HL-60, K562), with IC50 values of 0.379, 0.838, 0.763, 1.618, 1.179 and 2.653 μM[1].
Menin-MLL-IN-37 (1-2 μM; 7 days) induces differentiation of MV4-11 and MOLM-13 leukemia cells, resulting in increased surface expression levels of CD11b[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MV4-11, MOLM-13 leukemia cell lines
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Concentration:1000 nM, 2000 nM
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Incubation Time:7 days
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Result:Induced a significant increase in the percentage of CD11b-positive cells in MV4-11 cell line.
Induced a significant increase in the percentage of CD11b-positive cells in MOLM-13 cell line.
| Species | Dose | Route | Tmax | T1/2 | Cmax | AUC0-t | AUC0-∞ | MRT0-t | Vz/F | CL/F |
|---|---|---|---|---|---|---|---|---|---|---|
| Mice[1] | 20 mg/kg | i.g. | 1.67 h | 2.43 h | 537.00 ng/mL | 2241.09 ng·h/mL | 2379.51 ng·h/mL | 3.59 h | 30499.24 mL/kg | 147.32 mL/min/kg |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Molecular Weight 638.77
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Formula C29H37F3N6O3S2
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SMILES
FC(F)(F)CC1=CC2=C(NC3CCN(CC4CCN(C5=CC=C(S(=O)(N6CCOCC6)=O)C=C5)CC4)CC3)N=CN=C2S1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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