NPM1 - nucleophosmin 1 Gene

Also Known as B23; NPM

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4869

About NPM1

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:171,387,116-171,410,900 (from NCBI)

This gene has 33 transcripts (splice variants), 182 orthologues, 2 paralogues and is associated with 104 phenotypes. Ubiquitous expression in ovary (RPKM 256.2), lymph node (RPKM 146.3) and 25 other tissues.

Summary

The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]

NPM1 Products (7)

mRNA	Protein	Name
NM_001037738.3	NP_001032827.1	nucleophosmin isoform 3
NM_001355006.2	NP_001341935.1	nucleophosmin isoform 1
NM_001355007.2	NP_001341936.1	nucleophosmin isoform 4
NM_001355009.2	NP_001341938.1	nucleophosmin isoform 5
NM_001355010.2	NP_001341939.1	nucleophosmin isoform 6
NM_002520.7	NP_002511.1	nucleophosmin isoform 1
NM_199185.4	NP_954654.1	nucleophosmin isoform 2

NPM1 Protein Structure

Nucleoplasmin

0
100
200
294 a.a.

Protein Preferred Names	Protein Names
nucleophosmin	nucleolar protein NO38

NPM1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NPM1	P06748	RPL34	Homo sapiens	P49207	Anti Tag CoIP	35271311
Cross	NPM1	P06748	Cdkn2a	Mus musculus	Q64364	Anti Tag CoIP	16540653
Intra	NPM1	P06748	NPM2	Homo sapiens	Q86SE8-2	Validated Y2H	32296183
Intra	NPM1	P06748	TERT	Homo sapiens	O14746	Anti Tag CoIP	28255170
Intra	NPM1	P06748	TERT	Homo sapiens	O14746	Anti Bait CoIP	28255170
Intra	NPM1	P06748	KLK6	Homo sapiens	Q92876	Validated Y2H	32814053
Intra	NPM1	P06748	KLK6	Homo sapiens	Q92876	Y2H Array	32814053
Intra	NPM1	P06748	KLK6	Homo sapiens	Q92876	Y2H Pooling	32814053
Intra	NPM1	P06748	LARP4	Homo sapiens	Q71RC2	Anti Tag CoIP	26496610
Intra	NPM1	P06748	LARP4	Homo sapiens	Q71RC2	Anti Tag CoIP	35271311
Intra	NPM1	P06748	SENP3	Homo sapiens	Q9H4L4	Y2H	18259216
Intra	NPM1	P06748	SENP3	Homo sapiens	Q9H4L4	Anti Bait CoIP	18259216
Intra	NPM1	P06748	SENP3	Homo sapiens	Q9H4L4	Anti Tag CoIP	33961781
Intra	NPM1	P06748	HDAC2	Homo sapiens	Q92769	Anti Bait CoIP	17318229
Intra	NPM1	P06748	HDAC1	Homo sapiens	Q13547	Anti Tag CoIP	17318229
Intra	NPM1	P06748	HDAC1	Homo sapiens	Q13547	Anti Bait CoIP	17318229
Intra	NPM1	P06748	YWHAZ	Homo sapiens	P63104	Pull Down	15161933
Intra	NPM1	P06748	TFAP2A	Homo sapiens	P05549	Anti Tag CoIP	17318229
Intra	NPM1	P06748	TFAP2A	Homo sapiens	P05549	Pull Down	17318229
Intra	NPM1	P06748	CPSF1	Homo sapiens	Q10570	Anti Bait CoIP	21822216
Intra	NPM1	P06748	RPS6	Homo sapiens	P62753	Anti Tag CoIP	26496610
Intra	NPM1	P06748	KPNA3	Homo sapiens	O00505	Pull Down	20701745
Intra	NPM1	P06748	KPNA3	Homo sapiens	O00505	Anti Tag CoIP	35271311
Intra	NPM1	P06748	TP53	Homo sapiens	P04637	Anti Bait CoIP	15144954
Intra	NPM1	P06748	TP53	Homo sapiens	P04637	Crosslink	16376884
Intra	NPM1	P06748	TP53	Homo sapiens	P04637	SPR	16376884
Intra	NPM1	P06748	MDM2	Homo sapiens	Q00987	Pull Down	15144954
Intra	NPM1	P06748	MDM2	Homo sapiens	Q00987	Pull Down	22510990
Intra	NPM1	P06748	MDM2	Homo sapiens	Q00987	Anti Bait CoIP	15144954
Intra	NPM1	P06748	HEMGN	Homo sapiens	Q9BXL5	Anti Bait CoIP	22712502
Intra	NPM1	P06748	HEMGN	Homo sapiens	Q9BXL5	Anti Tag CoIP	22712502
Intra	NPM1	P06748	AURKA	Homo sapiens	O14965	IF	24857377
Intra	NPM1	P06748	AURKA	Homo sapiens	O14965	Protein Kinase Assay	24857377
Intra	NPM1	P06748	CCDC124	Homo sapiens	Q96CT7	Anti Tag CoIP	35271311
Intra	NPM1	P06748	CCDC124	Homo sapiens	Q96CT7	Confocal	38029384
Intra	NPM1	P06748	CCDC124	Homo sapiens	Q96CT7	Anti Tag CoIP	38029384
Intra	NPM1	P06748	AURKB	Homo sapiens	Q96GD4	Protein Kinase Assay	24857377
Intra	NPM1	P06748	AURKB	Homo sapiens	Q96GD4	IF	24857377
Intra	NPM1	P06748	AURKB	Homo sapiens	Q96GD4	Anti Tag CoIP	24857377
Intra	NPM1	P06748	CDKN2A	Homo sapiens	Q8N726	Anti Bait CoIP	16957780
Intra	NPM1	P06748	EIF2AK2	Homo sapiens	P19525	Anti Tag CoIP	33961781
Intra	NPM1	P06748	NPM2	Homo sapiens	Q86SE8	Y2H Array	25416956
Intra	NPM1	P06748	NIBAN1	Homo sapiens	Q9BZQ8	Pull Down	22510990
Intra	NPM1	P06748	NIBAN1	Homo sapiens	Q9BZQ8	Anti Bait CoIP	22510990
Intra	NPM1	P06748	PELP1	Homo sapiens	Q8IZL8	IF	21326211
Intra	NPM1	P06748	PELP1	Homo sapiens	Q8IZL8	Anti Tag CoIP	33961781
Intra	NPM1	P06748	PELP1	Homo sapiens	Q8IZL8	Anti Tag CoIP	21326211
Intra	NPM1	P06748	PINX1	Homo sapiens	Q96BK5	Anti Tag CoIP	28255170
Cross	NPM1	P06748	pre-C/C	Hepatitis B virus	B1Q2W9	Anti Bait CoIP	24462683
Cross	NPM1	P06748	pre-C/C	Hepatitis B virus	B1Q2W9	Density Sedimentation	24462683
Cross	NPM1	P06748	q98147_hhv8	Human herpesvirus 8	Q98147	Anti Bait CoIP	15144954
Cross	NPM1	P06748	L2	Human adenovirus C	P68951	Anti Bait CoIP	17602943
Cross	NPM1	P06748	L2	Human adenovirus C	P24938	Anti Bait CoIP	17602943
Cross	NPM1	P06748	PB2	Influenza A virus	P03427	SLC	23816991

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant NPM1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74680	Nucleophosmin/Npm1 Protein, Human (293a.a, His, soultion)	P06748-1 (E2-L294)	≥ 85%, as determined by reducing SDS-PAGE.
HY-P74681	Nucleophosmin/Npm1 Protein, Human (150a.a, His)	P06748-1 (M9-L158)	≥ 90%, as determined by reducing SDS-PAGE.

NPM1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P810640	Phospho-Nucleophosmin (Ser125) Antibody (YA9902)	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
HY-P81291	Nucleophosmin Antibody (YA1008)	WB, ChIP	Human, Mouse
HY-P81291A	Nucleophosmin Antibody (YA1009)	WB, IHC-P, IP	Human
HY-P81291AA	Nucleophosmin Antibody (YA1009)(PBS only)	WB, IHC-P, IP	Human
HY-P82877	Phospho-Nucleophosmin (Thr199) Antibody (YA2622)	WB, IHC-P, IP	Human, Rat
HY-P82877A	Phospho-Nucleophosmin (Thr199) Antibody (YA2622)(PBS only)	WB, IHC-P, IP	Human, Rat
HY-P86052	Nucleophosmin Antibody (YA5744)	IHC-P, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Aml With Myelodysplasia-Related Features	Acute Myeloid Leukemia With Multilineage Dysplasia Aml With Multilineage Dysplasia Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Leukemia, Acute Myeloid	Acute Myeloid Leukemia Leukemia, Acute Myelogenous Acute Myelogenous Leukemia AML Leukemia, Acute Myeloid, Susceptibility To Acute Myeloblastic Leukemia Leukemia, Acute Myeloid, Reduced Survival In, Somatic Acute Myeloid Leukaemia Leukemia, Myelocytic, Acute Therapy Related Acute Myeloid Leukemia And Myelodysplastic Syndrome Secondary Aml Acute Myelocytic Leukemia Acute Myeloid Leukemia, Somatic Leukemia, Acute Myeloid, Somatic Myeloid Leukemia, Acute, M4/M4eo Subtype, Somatic Acute Myeloblastic Leukaemia Acute Myelogenous Leukaemia Aml - Acute Myeloid Leukemia Acute Myeloid Leukemia With Cebpa Somatic Mutations Aml With Cebpa Somatic Mutations Inherited Acute Myeloid Leukemia Familial Aml Inherited Aml Pure Familial Aml Pure Familial Acute Myeloid Leukemia Secondary Acute Myeloid Leukemia Therapy-Related Aml And Myelodysplastic Syndrome Acute Myeloid Leukemia, Secondary Acute Non-Lymphoblastic Leukemia Acute Non-Lymphocytic Leukemia Acute Biphenotypic Leukemia Acute Undifferentiated Leukemia Acute Myeloblastic Leukaemia With Multilineage Dysplasia Acute Myeloid Leukaemia With Multilineage Dysplasia Without Mention Of Remission Acute Myeloid Leukaemia With Myelodysplasia-Related Features
Primary Cutaneous Anaplastic Large Cell Lymphoma	Primary C-Alcl Regressive Atypical Histiocytosis Lymphoma, Primary Cutaneous Anaplastic Large Cell
Acute Myeloid Leukemia With Npm1 Somatic Mutations	Aml With Npm1 Somatic Mutations
Lymphoproliferative Syndrome, X-Linked, 1	Lymphomatoid Papulosis Duncan Disease Purtilo Syndrome X-Linked Lymphoproliferative Syndrome Xlp X-Linked Lymphoproliferative Disease XLP1 Lyp Lymphoproliferative Disease, X-Linked Xlpd X-Linked Lymphoproliferative Disease Due To Sh2d1a Deficiency Ebv Infection, Severe, Susceptibility To Ebvs Immunodeficiency 5 Imd5 X-Linked Lymphoproliferative Syndrome 1 Epstein-Barr Virus Infection, Familial Fatal Ebv Infection, Severe Infectious Mononucleosis, Severe Infectious Mononucleosis, Severe, Susceptibility To Immunodeficiency, X-Linked Progressive Combined Variable Epstein Barr Virus Infection, Familial Fatal X-Linked Progressive Combined Variable Immunodeficiency 5 Epstein-Barr Virus-Induced Lymphoproliferative Disease In Males Familial Fatal Epstein-Barr Infection Severe Susceptibility To Ebv Infection Severe Susceptibility To Infectious Mononucleosis Sap Deficiency Sh2d1a/Slam-Associated Protein Deficiency X-Linked Lymphoproliferative Syndrome Type 1 X-Linked Progressive Combined Variable Immunodeficiency Lymphoproliferative Syndrome, X-Linked Sap X-Linked Lymphoproliferative Disorder
Acute Myeloblastic Leukemia Without Maturation	Aml M1 Acute Myeloblastic Leukemia M1 Acute Myeloblastic Leukemia Type 1
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic
Acute Myeloblastic Leukemia With Maturation	Aml M2 Acute Myeloblastic Leukemia M2 Acute Myeloblastic Leukemia Type 2 Lam M2 Acute Myeloid Leukemia
Dyskeratosis Congenita	Dyskeratosis Congenita Autosomal Dominant Dc Dkc Zinsser-Engman-Cole Syndrome Dyskeratosis Congenita, Autosomal Dominant Autosomal Dominant Dyskeratosis Congenita Dkca Dyskeratosis Congenita Scoggins Type Zinsser-Cole-Engman Syndrome X-Linked Dyskeratosis Congenita Hoyeraal-Hreidarsson Syndrome
Leukemia	Leukemias Leukaemia, Unspecified, Without Mention Of Remission Aleukemic Leukaemia Chronic Leukaemia Subacute Leukaemia Leukaemia Disorder Leukaemia Nos
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma
Myelodysplastic Syndrome	Myelodysplastic Syndromes Myelodysplasia MDS Myelodysplastic Syndrome Included Myelodysplastic Syndrome, Susceptibility To, Included Myelodysplastic Syndrome, Somatic Myelodysplastic Syndrome, Susceptibility To
Myeloid Leukemia	Myeloid Leukaemia Leukaemia Myelogenous Leukemia Myelogenous Myeloid Granulocytic Leukaemia Myeloid Granulocytic Leukemia Non-Lymphocytic Leukemia Leukemia, Myeloid Granulocytic Leukaemia Myelogenous Leukaemia Myeloid Leukaemia, Unspecified, Without Mention Of Remission
Reticulosarcoma	Histiocytic Lymphoma Large-Cell Lymphomas Lymphoma, Large-Cell Lymphoma Large Cell Diffuse Large B-Cell Lymphoma Histiocytic Sarcoma
B-Cell Lymphoma	Lymphoma, B-Cell B-Cell Lymphomas B-Cell Lymphocytic Neoplasm Lymphoma B-Cell B-Cell Lymphoma Nos
Childhood Lymphoma	Pediatric Lymphoma
Mycotic Corneal Ulcer
Lymphoma, Non-Hodgkin, Familial	Non-Hodgkin Lymphoma Lymphoma, Non-Hodgkin NHL Lymphoma, Non-Hodgkin, Somatic Lymphoma, Follicular, Somatic Familial Non-Hodgkin Lymphoma Lymphoma Non-Hodgkins Follicular Lymphoma, Somatic Lymphosarcoma Non-Hodgkins Lymphoma
Hematologic Cancer	Hematologic Neoplasm Hematologic Neoplasms Hematologic Malignancies Blood Cancer Hematologic Malignancy Hematological Tumors Hematopoietic And Lymphoid System Tumor Hematopoietic Cancer Hematopoietic Neoplasm Hematopoietic Tumors Malignant Hematopoietic Neoplasm Liquid Tumor Hematopoietic Neoplasms
Sarcoma	Connective And Soft Tissue Neoplasm Tumor Of Soft Tissue And Skeleton Sarcomas Sarcoma - Category
Basophilic Adenocarcinoma	Basophil Adenocarcinoma Basophil Carcinoma Basophilic Carcinoma
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Childhood Acute Myeloid Leukemia	Childhood Acute Myeloid Leukaemia Paediatric Acute Myeloid Leukaemia Pediatric Acute Myeloid Leukemia
Myeloid Sarcoma	Granulocytic Sarcoma Chloroma Extramedullary Myeloid Tumor Sarcoma, Granulocytic Sarcoma Granulocytic Sarcoma, Myeloid Myelosarcoma Myeloid Sarcoma Disease Myeloid Sarcoma Nos Myeloid Sarcoma Without Mention Of Remission
Myelofibrosis	Primary Myelofibrosis Agnogenic Myeloid Metaplasia Idiopathic Myelofibrosis Myeloid Metaplasia Myelofibrosis With Myeloid Metaplasia Osteomyelofibrosis Megakaryocytic Myelosclerosis Myelosclerosis Chronic Idiopathic Myelofibrosis Myelofibrosis, Idiopathic Myelofibrosis With Myeloid Metaplasia, Somatic Myelofibrosis, Somatic Aleukemic Myelosis Bone Marrow Fibrosis MYELOF MMM Agnogenic Myeloid Metaplasia With Myelofibrosis Ammm Myelosclerosis With Myeloid Metaplasia Myelofibrosis Nos
Core Binding Factor Acute Myeloid Leukemia	Cbf Acute Myeloid Leukemia Cbf-Aml Core-Binding Factor Aml
Childhood Leukemia
Aleukemic Leukemia Cutis
Chronic Leukemia	Adult Chronic Leukemia Cll Cml
Myelodysplastic/Myeloproliferative Neoplasm	Myelodysplastic-Myeloproliferative Diseases Myelodysplastic/Myeloproliferative Disease Myelodysplastic Myeloproliferative Cancer Myelodysplastic Myeloproliferative Disease Myeloproliferative/Myelodysplastic Syndromes
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Adult Lymphoma
Acute Myeloid Leukemia With Bcr-Abl1	Acute Myeleoid Leukemia With Bcr-Abl1
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Chronic Myelomonocytic Leukemia	Leukemia, Myelomonocytic, Chronic Cmml Leukemia Myelomonocytic Chronic Cmml - [Chronic Myelomonocytic Leukaemia] Chronic Myelomonocytic Leukaemia Without Mention Of Remission Chronic Monocytic Leukaemia Chronic Monocytoid Leukaemia
Hematuria, Benign Familial	Benign Familial Hematuria BFH Thin Membrane Nephropathy Tmn Thin Basement Membrane Nephropathy Thin-Basement-Membrane Nephropathy Hematuria, Familial Benign Hematuria Benign Familial Hematuria, Benign, Familial Thin Basement Membrane Disease
Bone Marrow Cancer	Malignant Neoplasm Of Bone Marrow Bone Marrow Neoplasm Bone Marrow Tumor Malignant Bone Marrow Tumor Myeloproliferative Disorders Bone Marrow Neoplasms Myeloproliferative Disease Chronic Myeloproliferative Disorder
Thyroid Gland Hurthle Cell Carcinoma	Oncocytic Carcinoma Of The Thyroid Thyroid Cancer, Hurthle Cell
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Neuroblastoma	Nb Neuroblastoma, Susceptibility To Neuroblastomas Central Neuroblastoma
Ovarian Cancer	Ovarian Carcinoma Ovarian Neoplasm Malignant Tumour Of Ovary Cancer Of The Ovary Epithelial Ovarian Cancer Neoplasm Of Ovary Ovarian Neoplasms Ovarian Cancers Malignant Neoplasm Of Ovary Primary Malignant Neoplasm Of Ovary Ovarian Cancer, Somatic Malignant Ovarian Tumor Ovary Neoplasm Primary Ovarian Cancer Tumor Of The Ovary Malignant Neoplasm Of The Ovary Malignant Tumor Of The Ovary Ovarian Malignant Tumor OC Ovarian Carcinomas Cancer, Ovarian Cancer Of Ovary Ovary Cancer Ca Ovary
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Giant Axonal Neuropathy 1, Autosomal Recessive	Giant Axonal Neuropathy Giant Axonal Neuropathy 1 Gan GAN1 Giant Axonal Neuropathy-1 Neuropathy, Giant Axonal Giant Axonal Disease Neuropathy, Axonal, Giant, Type 1
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Juvenile Myelomonocytic Leukemia	Leukemia, Juvenile Myelomonocytic JMML Leukemia, Juvenile Myelomonocytic, Somatic Juvenile Chronic Myelomonocytic Leukemia Juvenile Chronic Myelogenous Leukemia Leukemia, Myelomonocytic, Juvenile Juvenile Myelomonocytic Leukaemia Without Mention Of Remission
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Leukemia, Chronic Myeloid	Chronic Myeloid Leukemia Chronic Myelogenous Leukemia CML Chronic Granulocytic Leukemia Leukemia, Philadelphia Chromosome-Positive, Resistant To Imatinib Chronic Myeloid Leukaemia Chronic Granulocytic Leukaemia Chronic Myelogenous Leukaemia Myeloid Leukemia, Chronic Leukemia, Chronic Myelogenous Leukemia, Chronic Myeloid, Philadelphia Chromosome Positive, Somatic Cml - Chronic Myelogenous Leukemia Cgl Chronic Myelocytic Leukemia Leukemia, Chronic Myeloid, Atypical ACML Atypical Chronic Myeloid Leukemia Bcr-Abl1 Negative Myeloid Leukemia Chronic Leukemia, Myeloid, Chronic Leukemia, Myeloid, Chronic, Atypical, Bcr-Abl Negative Cml- [Chronic Myeloid Leukaemia] Cgl - [Chronic Granulocytic Leukaemia] Chronic Myelocytic Leukaemia
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome
Leukemia, Chronic Lymphocytic	Chronic Lymphocytic Leukemia B-Cell Chronic Lymphocytic Leukemia CLL B-Cell Chronic Lymphoid Leukemia Chronic Lymphatic Leukemia Chronic Lymphocytic Leukaemia Lymphoplasmacytic Leukemia Small Lymphocytic Lymphoma Leukemia, Chronic Lymphatic B-Cell Chronic Lymphocytic Leukaemia Chronic Lymphatic Leukaemia Lymphoplasmacytic Leukaemia B Cell Chronic Lymphocytic Leukemia Chronic B-Cell Lymphocytic Leukemia Leukemia, Lymphocytic, Chronic B-Cll Chronic Lymphoid Leukemia Leukemia Lymphocytic Chronic Lymphoma Small Lymphocytic Leukemia, Lymphocytic, Chronic, B-Cell
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (19)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156794	Enzomenib	Inhibitor	99.88%	Unkown
HY-136360	MI-3454	Inhibitor	98.03%	Unkown
HY-162350	TDI-11055		98.18%	Unkown
HY-162265A	UCM-13369 dihydrochloride	Inducer	99.87%	Unkown
HY-172416	Balomenib	Inhibitor	99.81%	Unkown
HY-N10264	Avrainvillamide		95.08%	Unkown
HY-164279	YTR107		95.33%	Unkown
HY-156794A	Enzomenib enantiomer	Inhibitor	98.01%	Unkown
HY-162265	UCM-13369	Inducer	/	Unkown
HY-114162B	VTP50469 mesylate		/	Unkown
HY-122670	VS-II-173		/	Unkown
HY-181690	Menin-MLL-IN-37	Inhibitor	/	Unkown
HY-208723	MAP3K1-IN-1	Inhibitor	/	Unkown
HY-E70760	NPM1 ALK Recombinant Human Active Protein Kinase		/	Unkown
HY-E70761	NPM1 ALK F1174L Recombinant Human Active Protein Kinase		/	Unkown
HY-RS09490	NPM1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17071	Npm1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18762	Gja1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23515	Npm1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	NPM1	VGNC	VGNC:97533
Rattus norvegicus	NPM1	RGD	RGD:3192
Mus musculus	NPM1	MGD	MGI:106184
Others	NPM1	NCBI