NPM2 - nucleophosmin/nucleoplasmin 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10361

About NPM2

Cytogenetic location: 8p21.3 Genomic coordinates (GRCh38): 8:22,024,134-22,036,897 (from NCBI)

This gene has 14 transcripts (splice variants), 150 orthologues and 2 paralogues. Biased expression in thyroid (RPKM 3.7), brain (RPKM 3.7) and 12 other tissues.

Summary

Predicted to enable RNA binding activity; chromatin binding activity; and histone binding activity. Involved in several processes, including blastocyst development; oocyte differentiation; and regulation of cell cycle process. Located in chromatin and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NPM2 Products (12)

mRNA Protein Name
NM_001286680.2 NP_001273609.1 nucleoplasmin-2 isoform 1
NM_001286681.2 NP_001273610.1 nucleoplasmin-2 isoform 2
NM_001413113.1 NP_001400042.1 nucleoplasmin-2 isoform 1
NM_001413114.1 NP_001400043.1 nucleoplasmin-2 isoform 3
NM_001413115.1 NP_001400044.1 nucleoplasmin-2 isoform 4
NM_001413116.1 NP_001400045.1 nucleoplasmin-2 isoform 1
NM_001413117.1 NP_001400046.1 nucleoplasmin-2 isoform 5
NM_001413118.1 NP_001400047.1 nucleoplasmin-2 isoform 5
NM_001413119.1 NP_001400048.1 nucleoplasmin-2 isoform 5
NM_001413120.1 NP_001400049.1 nucleoplasmin-2 isoform 4
NM_001413121.1 NP_001400050.1 nucleoplasmin-2 isoform 2
NM_182795.2 NP_877724.1 nucleoplasmin-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in blastocyst development IMP
IMP: Inferred from mutant phenotype
12714744 GOA
involved in chromatin remodeling IDA
IDA: Inferred from direct assay
12714744 GOA
involved in oocyte differentiation IEP
IEP: Inferred from expression pattern
12714744 GOA
involved in positive regulation of meiotic nuclear division IMP
IMP: Inferred from mutant phenotype
12714744 GOA
involved in regulation of exit from mitosis IMP
IMP: Inferred from mutant phenotype
12714744 GOA
involved in single fertilization IMP
IMP: Inferred from mutant phenotype
12714744 GOA
Cellular Component GO Annotation Evidence References Source
located in chromatin IDA
IDA: Inferred from direct assay
12714744 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12714744 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPM2 Protein Structure

Nucleoplasmin

Nucleoplasmin: Nucleoplasmin/nucleophosmin domain (15 - 165)

  • 0
  • 100
  • 200
  • 214 a.a.
Protein Preferred Names Protein Names

nucleoplasmin-2

NPM2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NPM2 Q86SE8 NPM3 Homo sapiens O75607
Y2H Array
31515488
Intra
NPM2 Q86SE8 NPM3 Homo sapiens O75607
Y2H Prey Pooling
25416956
Intra
NPM2 Q86SE8 NPM3 Homo sapiens O75607
Anti Tag CoIP
33961781
Intra
NPM2 Q86SE8 NPM3 Homo sapiens O75607
Y2H Array
25416956
Intra
NPM2 Q86SE8 NPM3 Homo sapiens O75607
Anti Tag CoIP
28514442
Intra
NPM2 Q86SE8 NPM3 Homo sapiens O75607
Validated Y2H
25416956
Intra
NPM2 Q86SE8 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
25416956
Intra
NPM2 Q86SE8 SDCBP2 Homo sapiens Q9H190
Y2H Array
25416956
Intra
NPM2 Q86SE8 SDCBP2 Homo sapiens Q9H190
Y2H Array
31515488
Intra
NPM2 Q86SE8 NPM1 Homo sapiens P06748
Validated Y2H
25416956
Intra
NPM2 Q86SE8 NPM1 Homo sapiens P06748
Anti Tag CoIP
33961781
Intra
NPM2 Q86SE8 NPM1 Homo sapiens P06748
Y2H Prey Pooling
25416956
Intra
NPM2 Q86SE8 NPM1 Homo sapiens P06748
Y2H Array
31515488
Intra
NPM2 Q86SE8 NPM1 Homo sapiens P06748
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

NPM2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84655 NPM2 Antibody (YA4352) IHC-P, ICC/IF, ELISA Human
HY-P84655A NPM2 Antibody (YA4352)(PBS only) IHC-P, ICC/IF, ELISA Human
HY-P84656 NPM2 Antibody (YA4353) IHC-P, FC, ELISA Human
HY-P84656A NPM2 Antibody (YA4353)(PBS only) IHC-P, FC, ELISA Human

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09491 NPM2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NPM2 VGNC VGNC:75384
Felis catus NPM2 VGNC VGNC:107356
Mus musculus NPM2 MGD MGI:1890811
Bos taurus NPM2 VGNC VGNC:32207
Rattus norvegicus NPM2 RGD RGD:727816
Others NPM2 NCBI