Cd74 - CD74 molecule Gene

Also Known as INVG34

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25599

Summary

Predicted to enable several functions, including amyloid-beta binding activity; macrophage migration inhibitory factor binding activity; and signaling receptor binding activity. Predicted to contribute to cytokine binding activity. Involved in cell population proliferation and positive regulation of MAPK cascade. Predicted to be located in several cellular components, including Golgi apparatus; external side of plasma membrane; and multivesicular body. Predicted to be integral component of membrane. Predicted to be part of MHC class II protein complex; NOS2-CD74 complex; and macrophage migration inhibitory factor receptor complex. Predicted to be active in cell surface and cytoplasm. Orthologous to human CD74 (CD74 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd74 Products (1)

mRNA Protein Name
NM_013069.2 NP_037201.1 H-2 class II histocompatibility antigen gamma chain

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
12782713 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

H-2 class II histocompatibility antigen gamma chain

  • Cd74 molecule, major histocompatibility complex, class II invariant chain

  • MHC class II-associated invariant chain

  • ia antigen-associated invariant chain

  • ii

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99731 Milatuzumab Inhibitor 99.39% Phase 2

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P1826 CLIP (86-100) 98.39% Unkown
HY-P11303 PADRE peptide Ligand 98.28% Unkown
HY-103333 Arvanil Inhibitor 99.1% Unkown
HY-N2245 Schisandrone Inhibitor 99.78% Unkown
HY-107101 (5R)-5-Hydroxytriptolide Inhibitor 99.67% Unkown
HY-128356 SPL-410 Inhibitor 99.38% Unkown
HY-D3334 PE-CF594 / Unkown
Bioactive MoleculesInhibitory Antibodies (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990728 Bezetabart Inhibitor 99.00% Unkown
HY-P991837 Anti-HLA-DP Antibody (B7/21) Inhibitor / Unkown
HY-P991844 Anti-HLA-DQ Antibody (1a3) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd74 NCBI NCBI:972
Mus musculus Cd74 NCBI NCBI:16149