(5R)-5-Hydroxytriptolide
(Synonyms: PG 701; LLDT-8; 5α-Hydroxytriptolide)
Customer Review
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(5R)-5-Hydroxytriptolide is an extracted compound from Tripterygium, and shows lower cell cytotoxicity and higher immunosuppressive activity. (5R)-5-Hydroxytriptolide can be used for study of rheumatoid arthritis.
For research use only. We do not sell to patients.
- Purity: 99.67%
- CAS No.: 583028-68-6
- Formula: C20H24O7
- Molecular Weight:376.40
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
(5R)-5-Hydroxytriptolide is an extracted compound from Tripterygium, and shows lower cell cytotoxicity and higher immunosuppressive activity. (5R)-5-Hydroxytriptolide can be used for study of rheumatoid arthritis[1].
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.04 nM
Compound: 7; LLDT-8
|
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human A549 cells assessed as decrease in cell viability after 72 hrs by MTT assay
|
[PMID: 31121546] |
| BGC-823 | IC50 |
1.5 μM
Compound: 7; LLDT-8
|
Cytotoxicity against human BGC823 cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human BGC823 cells assessed as decrease in cell viability by MTT assay
|
[PMID: 31121546] |
| HeLa | IC50 |
0.34 μM
Compound: 7; LLDT-8
|
Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human HeLa cells assessed as decrease in cell viability by MTT assay
|
[PMID: 31121546] |
| HL-60 | IC50 |
0.04 nM
Compound: 7; LLDT-8
|
Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human HL60 cells assessed as decrease in cell viability after 72 hrs by MTT assay
|
[PMID: 31121546] |
| HL-60 | IC50 |
0.47 μM
Compound: 7; LLDT-8
|
Cytotoxicity against human HL60 cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human HL60 cells assessed as decrease in cell viability by MTT assay
|
[PMID: 31121546] |
| KB | IC50 |
0.3 μM
Compound: 7; LLDT-8
|
Cytotoxicity against human KB cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human KB cells assessed as decrease in cell viability by MTT assay
|
[PMID: 31121546] |
| MCF7 | IC50 |
0.04 nM
Compound: 7; LLDT-8
|
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability after 72 hrs by MTT assay
|
[PMID: 31121546] |
| MCF7 | IC50 |
1.05 μM
Compound: 7; LLDT-8
|
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by MTT assay
Cytotoxicity against human MCF7 cells assessed as decrease in cell viability by MTT assay
|
[PMID: 31121546] |
| MKN-28 | IC50 |
0.04 nM
Compound: 7; LLDT-8
|
Cytotoxicity against human MKN28 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against human MKN28 cells assessed as decrease in cell viability after 72 hrs by MTT assay
|
[PMID: 31121546] |
| P388 | IC50 |
0.04 nM
Compound: 7; LLDT-8
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Cytotoxicity against mouse P388 cells assessed as decrease in cell viability after 72 hrs by MTT assay
Cytotoxicity against mouse P388 cells assessed as decrease in cell viability after 72 hrs by MTT assay
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[PMID: 31121546] |
| PC-3 | IC50 |
0.275 μM
Compound: 4
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Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
Cytotoxicity against human PC3 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
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[PMID: 25467158] |
| U-251 | IC50 |
0.488 μM
Compound: 4
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Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
Cytotoxicity against human U251 cells assessed as inhibition of cell proliferation by sulforhodamine B assay
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[PMID: 25467158] |
Chemical Information
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CAS No. 583028-68-6
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Appearance Solid
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Molecular Weight 376.40
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Formula C20H24O7
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Color White to off-white
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SMILES
CC([C@@]12[C@H]([C@H]3[C@]4([C@@]5(C)CCC6=C(COC6=O)[C@]5(O)C[C@H]7[C@@]4(O7)[C@@H]2O)O3)O1)C
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Synonyms
PG 701; LLDT-8; 5α-Hydroxytriptolide
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
Select Batch:
Purity:
99.98%
Assay:
99.98%
ee.:
99.98%
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Calculators
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(5R)-5-Hydroxytriptolide Related Classifications
HY-107101 Related Classifications
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