Plau - plasminogen activator, urokinase Gene

Also Known as UPAM

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25619

Summary

Enables peptidase activity. Involved in several processes, including cellular response to hepatocyte growth factor stimulus; cellular response to staurosporine; and positive regulation of ovulation. Located in extracellular space and membrane. Used to study several diseases, including alcoholic liver cirrhosis; lung disease (multiple); sciatic neuropathy; status epilepticus; and transient cerebral ischemia. Biomarker of brain disease (multiple); end stage renal disease; myocardial infarction; sciatic neuropathy; and thrombosis. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease (multiple); Quebec platelet disorder; end stage renal disease; lung disease (multiple); and mitral valve prolapse. Orthologous to human PLAU (plasminogen activator, urokinase). [provided by Alliance of Genome Resources, Apr 2022]

Plau Products (1)

mRNA Protein Name
NM_013085.3 NP_037217.3 urokinase-type plasminogen activator precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables peptidase activity IDA
IDA: Inferred from direct assay
2509088 RGD
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
15854129 RGD
involved in cellular response to fluid shear stress IEP
IEP: Inferred from expression pattern
19166201 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
17953365 RGD
involved in cellular response to hepatocyte growth factor stimulus IEP
IEP: Inferred from expression pattern
19834131 RGD
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
19490965 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
19184369 RGD
involved in cellular response to staurosporine IEP
IEP: Inferred from expression pattern
19137075 RGD
involved in embryo implantation IEP
IEP: Inferred from expression pattern
15019809 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
16899994 RGD
involved in positive regulation of reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
16456094 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
9315743 RGD
involved in regulation of hepatocyte proliferation IMP
IMP: Inferred from mutant phenotype
17587687 RGD
involved in response to activity IEP
IEP: Inferred from expression pattern
22592543 RGD
involved in response to hepatocyte growth factor IEP
IEP: Inferred from expression pattern
21843593 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
19099788 RGD
involved in skeletal muscle tissue regeneration IMP
IMP: Inferred from mutant phenotype
12919869 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
17712486 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
10727258 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

urokinase-type plasminogen activator

  • U-plasminogen activator

  • Urinary plasminogen activator, urokinase

  • uPA

  • urokinase plasminogen activator

Recombinant Plau Proteins

Cat. No. Product Name Accession Purity
HY-P73561 PLAU/uPA Protein, Rat (HEK293, His) Q3KR76/NP_037217.3 (G20-F432) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10647 PLAU Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17095 Plau Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-183939 L1-CIDE-BRM1-13 / Unkown
HY-RS23539 Plau Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plau NCBI NCBI:5328