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Fn1 - fibronectin 1 Gene

Also Known as fn-1; FIBNEC

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 25661

Summary

Enables mercury ion binding activity and protease binding activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to mercury ion; and cellular response to peptide. Located in basement membrane and extracellular space. Used to study diabetic angiopathy; hypertension; and renovascular hypertension. Biomarker of several diseases, including artery disease (multiple); calcium oxalate nephrolithiasis; iron deficiency anemia; membranoproliferative glomerulonephritis; and ureteral obstruction. Human ortholog(s) of this gene implicated in calcium oxalate nephrolithiasis; membranoproliferative glomerulonephritis; and spondylometaphyseal dysplasia corner fracture type. Orthologous to human FN1 (fibronectin 1). [provided by Alliance of Genome Resources, Apr 2022]

Fn1 Products (1)

mRNA	Protein	Name
NM_019143.2	NP_062016.2	fibronectin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables mercury ion binding	IDA IDA: Inferred from direct assay	11768240	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	18039280	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10640397	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cell-matrix adhesion	IMP IMP: Inferred from mutant phenotype	12388756	RGD
involved in cellular response to BMP stimulus	IEP IEP: Inferred from expression pattern	12619935	RGD
involved in cellular response to amyloid-beta	IEP IEP: Inferred from expression pattern	11698153	RGD
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	20942814	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	22732364	RGD
involved in cellular response to interleukin-1	IMP IMP: Inferred from mutant phenotype	12679595	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	11819312	RGD
involved in cellular response to mercury ion	IDA IDA: Inferred from direct assay	11768240	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	15627306	RGD
involved in cellular response to prostaglandin E stimulus	IEP IEP: Inferred from expression pattern	15833739	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	16669970	RGD
involved in cellular response to vascular endothelial growth factor stimulus	IEP IEP: Inferred from expression pattern	23269647	RGD
involved in extracellular matrix organization	IMP IMP: Inferred from mutant phenotype	12388756	RGD
involved in glial cell migration	IDA IDA: Inferred from direct assay	19172391	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15677310	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	15980055	RGD
involved in positive regulation of cell migration	IMP IMP: Inferred from mutant phenotype	10634931	RGD
involved in positive regulation of chemotaxis	IDA IDA: Inferred from direct assay	11456126	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	23383330	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	15539768	RGD
involved in response to iron ion	IEP IEP: Inferred from expression pattern	18723004	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	12482021	RGD
involved in response to ozone	IEP IEP: Inferred from expression pattern	9700094	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	23383330	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in basement membrane	IDA IDA: Inferred from direct assay	14656002	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	11352844	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
fibronectin	FN fibronectin 2 fibronectin 3

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-138657	NCGC00378430	Inhibitor	98.07%	Unkown
HY-RS05013	FN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P5237	Tetrapeptide-4	Activator	99.54%	Unkown
HY-179410	Galectin-3-IN-7	Inhibitor	/	Unkown
HY-RS16767	Fn1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23207	Fn1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Bioactive MoleculesInhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992066	Anti-Mouse DDR2 Antibody (DAB0065)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fn1	NCBI	NCBI:2335