Igfbp2 - insulin-like growth factor binding protein 2 Gene

Also Known as IBP-2; BRL-BP; IGFBP-2; ILGFBPA

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25662

Summary

Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including response to estradiol; response to estrogen; and response to retinoic acid. Located in apical plasma membrane; cytoplasmic vesicle; and extracellular space. Biomarker of hypertension and hypothyroidism. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (Insulin like growth factor binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Igfbp2 Products (1)

mRNA Protein Name
NM_013122.2 NP_037254.2 insulin-like growth factor-binding protein 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables insulin-like growth factor I binding IDA
IDA: Inferred from direct assay
2538475 RGD
enables insulin-like growth factor I binding IMP
IMP: Inferred from mutant phenotype
2538475 RGD
enables insulin-like growth factor II binding IDA
IDA: Inferred from direct assay
1709938 RGD
enables insulin-like growth factor II binding IPI
IPI: Inferred from physical interaction
2538475 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hormone stimulus IEP
IEP: Inferred from expression pattern
16720626 RGD
involved in female pregnancy IEP
IEP: Inferred from expression pattern
17123939 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
10842239 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
12801995 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
15705658 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
17308996 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
15576465 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
7536658 RGD
involved in response to retinoic acid IEP
IEP: Inferred from expression pattern
11880314 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
10842239 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
15613074 RGD
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10842239 RGD
located in extracellular region IDA
IDA: Inferred from direct assay
2426267 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
2538475 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

insulin-like growth factor-binding protein 2

  • IGF-binding protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06625 IGFBP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174651 Human IGFBP2 mRNA / Unkown
HY-RS16821 Igfbp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23261 Igfbp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991042 Anti-IGFBP2 Antibody (M14) Antagonist ≥99.0% Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Igfbp2 NCBI NCBI:3485