Has2 - hyaluronan synthase 2 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25694

Summary

Enables hyaluronan synthase activity. Involved in several processes, including estrous cycle; hyaluronan biosynthetic process; and positive regulation of cell migration. Predicted to be located in cytoplasmic vesicle and plasma membrane raft. Predicted to be integral component of plasma membrane. Biomarker of diabetes insipidus; middle cerebral artery infarction; and pulmonary hypertension. Orthologous to human HAS2 (hyaluronan synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

Has2 Products (1)

mRNA Protein Name
NM_013153.2 NP_037285.1 hyaluronan synthase 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables hyaluronan synthase activity IDA
IDA: Inferred from direct assay
19635555 RGD
Biological Process GO Annotation Evidence References Source
involved in estrous cycle IEP
IEP: Inferred from expression pattern
24218629 RGD
involved in hyaluronan biosynthetic process IEP
IEP: Inferred from expression pattern
19635555 RGD
involved in kidney development IEP
IEP: Inferred from expression pattern
17706761 RGD
involved in positive regulation of hyaluronan biosynthetic process IDA
IDA: Inferred from direct assay
12186949 RGD
involved in positive regulation of hyaluronan biosynthetic process IMP
IMP: Inferred from mutant phenotype
17080198 RGD
involved in positive regulation of keratinocyte migration IDA
IDA: Inferred from direct assay
12186949 RGD
involved in positive regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
12186949 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
17080198 RGD
involved in positive regulation of substrate adhesion-dependent cell spreading IMP
IMP: Inferred from mutant phenotype
12186949 RGD
involved in positive regulation of urine volume IEP
IEP: Inferred from expression pattern
19635555 RGD
involved in regulation of extracellular matrix assembly IMP
IMP: Inferred from mutant phenotype
27094859 RGD
involved in renal water absorption IEP
IEP: Inferred from expression pattern
19635555 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

hyaluronan synthase 2

  • HA synthase 2

  • hyaluronate synthase 2

  • hyaluronic acid synthase 2

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. 상품명 효과
Purity Rare Diseases
HY-14803 Tasimelteon Agonist 99.16% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명 효과
Purity Phase
HY-131686 Ganglioside GT1b (bovine) ammonium Activator 98.0% Phase 4

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-N0008 Orcinol glucoside 98.92% Unkown
HY-P2096 Hexapeptide-11 99.77% Unkown
HY-116973 L 738372 Inhibitor / Unkown
HY-RS06007 HAS2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-14803S Tasimelteon-d5 Agonist / Unkown
HY-RS17492 Has2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23949 Has2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Has2 NCBI NCBI:3037