Cntf - ciliary neurotrophic factor Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25707

Summary

Enables ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in several processes, including membrane hyperpolarization; neurogenesis; and positive regulation of cell communication. Located in several cellular components, including axon; neuronal cell body; and plasma membrane bounded cell projection cytoplasm. Used to study Huntington's disease and glaucoma. Biomarker of hyperglycemia and retinitis pigmentosa. Human ortholog(s) of this gene implicated in Huntington's disease; disease of mental health; glaucoma; multiple sclerosis; and obesity. Orthologous to human CNTF (ciliary neurotrophic factor). [provided by Alliance of Genome Resources, Apr 2022]

Cntf Products (1)

mRNA Protein Name
NM_013166.2 NP_037298.2 ciliary neurotrophic factor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ciliary neurotrophic factor receptor binding IPI
IPI: Inferred from physical interaction
1648265 RGD
enables cytokine activity IDA
IDA: Inferred from direct assay
8385113 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
8385113 RGD
Biological Process GO Annotation Evidence References Source
involved in astrocyte activation IDA
IDA: Inferred from direct assay
11771938 RGD
involved in axon regeneration IDA
IDA: Inferred from direct assay
16699509 RGD
involved in cell surface receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
15342787 RGD
involved in membrane hyperpolarization IDA
IDA: Inferred from direct assay
15831538 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: Inferred from direct assay
15574731 RGD
involved in nervous system development IDA
IDA: Inferred from direct assay
11932952 RGD
involved in positive regulation of MAPK cascade IDA
IDA: Inferred from direct assay
15574731 RGD
involved in positive regulation of axon regeneration IDA
IDA: Inferred from direct assay
15574731 RGD
involved in positive regulation of cell growth IDA
IDA: Inferred from direct assay
11771938 RGD
involved in positive regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15831538 RGD
involved in positive regulation of hormone secretion IDA
IDA: Inferred from direct assay
11771938 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: Inferred from direct assay
15574731 RGD
involved in positive regulation of protein modification process IDA
IDA: Inferred from direct assay
14725620 RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT IDA
IDA: Inferred from direct assay
15574731 RGD
involved in regulation of resting membrane potential IDA
IDA: Inferred from direct assay
15831538 RGD
involved in response to electrical stimulus IEP
IEP: Inferred from expression pattern
19576889 RGD
involved in response to light intensity IEP
IEP: Inferred from expression pattern
21076359 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
12849744 RGD
located in glial cell projection IDA
IDA: Inferred from direct assay
14725620 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
12849744 RGD
located in plasma membrane bounded cell projection cytoplasm IDA
IDA: Inferred from direct assay
12849744 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ciliary neurotrophic factor

  • ciliary neurotropic factor

Recombinant Cntf Proteins

Cat. No. Product Name Accession Purity
HY-P7148 CNTF Protein, Rat P20294 (A2-M200) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P7148A CNTF Protein, Rat (His) P20294 (A2-M200) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-D0889 Glycylglycine 99.90% Unkown
HY-D0889R Glycylglycine (Standard) 99.91% Unkown
HY-184832 P021 Inhibitor / Unkown
HY-RS02923 CNTF Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16555 Cntf Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22988 Cntf Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W040074 Glycylglycine hydrochloride hydrate / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cntf NCBI NCBI:1270