Slc11a2 - solute carrier family 11 member 2 Gene

Also Known as Dmt1; Nramp2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25715

Summary

Enables lead ion transmembrane transporter activity; transition metal ion binding activity; and transition metal ion transmembrane transporter activity. Involved in several processes, including cellular response to tumor necrosis factor; response to lead ion; and transition metal ion transport. Located in apical part of cell; late endosome membrane; and lysosomal membrane. Is integral component of membrane. Used to study Parkinsonism; hypochromic anemia; and pneumonia. Biomarker of brain ischemia; duodenal ulcer; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc11a2 Products (2)

mRNA Protein Name
NM_001399169.1 NP_001386098.1 natural resistance-associated macrophage protein 2 isoform 2
NM_013173.2 NP_037305.2 natural resistance-associated macrophage protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables cadmium ion binding IDA
IDA: Inferred from direct assay
9242408 RGD
enables cadmium ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
9242408 RGD
enables cobalt ion binding IDA
IDA: Inferred from direct assay
9242408 RGD
enables cobalt ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
9242408 RGD
enables copper ion binding IDA
IDA: Inferred from direct assay
9242408 RGD
enables copper ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
9242408 RGD
enables ferrous iron transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
16091957 RGD
enables iron ion binding IDA
IDA: Inferred from direct assay
9242408 RGD
enables iron ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
9242408 RGD
enables lead ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
9242408 RGD
enables manganese ion binding IDA
IDA: Inferred from direct assay
9242408 RGD
enables manganese ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
9242408 RGD
enables nickel cation binding IDA
IDA: Inferred from direct assay
9242408 RGD
enables nickel cation transmembrane transporter activity IDA
IDA: Inferred from direct assay
9242408 RGD
enables zinc ion binding IDA
IDA: Inferred from direct assay
9242408 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
21325818 RGD
involved in cellular response to iron ion IEP
IEP: Inferred from expression pattern
17663481 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
16221503 RGD
involved in copper ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
22442359 RGD
involved in iron ion transport IMP
IMP: Inferred from mutant phenotype
16091957 RGD
involved in response to cadmium ion IEP
IEP: Inferred from expression pattern
19083094 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
21325818 RGD
involved in response to iron ion IEP
IEP: Inferred from expression pattern
12876064 RGD
involved in response to lead ion IEP
IEP: Inferred from expression pattern
19083094 RGD
involved in response to manganese ion IEP
IEP: Inferred from expression pattern
17060373 RGD
involved in response to manganese ion IMP
IMP: Inferred from mutant phenotype
18849539 RGD
involved in transition metal ion transport IDA
IDA: Inferred from direct assay
9242408 RGD
Cellular Component GO Annotation Evidence References Source
located in apical part of cell IDA
IDA: Inferred from direct assay
18420243 RGD
located in late endosome membrane IDA
IDA: Inferred from direct assay
16449358 RGD
located in lysosomal membrane IDA
IDA: Inferred from direct assay
16449358 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

natural resistance-associated macrophage protein 2

  • DMT-1

  • NRAMP 2

  • Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)

  • divalent cation transporter 1

  • divalent metal transporter 1

  • solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2

  • solute

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180199 GPX4-IN-21 / Unkown
HY-RS12995 SLC11A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20644 Slc11a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27154 Slc11a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc11a2 NCBI NCBI:4891