2. Gene
  3. Ppara - peroxisome proliferator activated receptor alpha Gene

Ppara - peroxisome proliferator activated receptor alpha Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PPAR

Gene ID: 25747 | Gene type: protein coding

About Ppara

Primary_assembly 7: 116,832,756-116,895,346 forward strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 455 orthologues, 19 paralogues and is associated with 61 phenotypes. Biased expression in Liver (RPKM 134.1), Kidney (RPKM 127.) and 9 other tissues.

Summary

Enables several functions, including MDM2/MDM4 family protein binding activity; NFAT protein binding activity; and nuclear receptor activity. Involved in several processes, including behavioral response to nicotine; negative regulation of cell growth involved in cardiac muscle cell development; and response to ethanol. Located in nucleus. Used to study hepatocellular carcinoma; hypertension; hypertensive encephalopathy; and periodontitis. Biomarker of alcoholic hepatitis; fatty liver disease; hydrocephalus; and hypertension. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Ppara Products(1)

mRNA Protein Name
NM_013196.2 NP_037328.1 peroxisome proliferator-activated receptor alpha

Ppara Protein Structure

NR_DBD_Ppar

NR_DBD_Ppar: cd06965 (237 - 320)

NR_LBD_PPAR

NR_LBD_PPAR: cd06932 (337 - 603)

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  • 605 a.a.
Protein Preferred Names Protein Names

peroxisome proliferator-activated receptor alpha

PPAR-alpha

nuclear receptor subfamily 1 group C member 1

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-14728 Aleglitazar Agonist 99.74% Phase 3
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10919 PPARA Human Pre-designed siRNA Set A / Unkown
HY-RS10920 Ppara Mouse Pre-designed siRNA Set A / Unkown
HY-RS10921 Ppara Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppara NCBI NCBI:5465