Map2k4 - mitogen-activated protein kinase kinase 4 Gene

Also Known as MEK4; MKK4; Sek1; JNKK1; Serk1; PRKMK4; MAPKK 4

Species: Mus musculus

Gene Type: protein coding
Gene ID: 26398

Summary

Predicted to enable ATP binding activity; JUN kinase kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in positive regulation of smooth muscle cell apoptotic process. Acts upstream of or within MAPK cascade; negative regulation of motor neuron apoptotic process; and response to wounding. Predicted to be located in several cellular components, including axon; dendrite cytoplasm; and perikaryon. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in colorectal cancer; ovarian serous carcinoma; pancreatic cancer; respiratory system Cancer (multiple); and urinary bladder Cancer. Orthologous to human MAP2K4 (mitogen-activated protein kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Map2k4 Products (6)

mRNA Protein Name
NM_001316367.1 NP_001303296.1 dual specificity mitogen-activated protein kinase kinase 4 isoform a
NM_001316368.1 NP_001303297.1 dual specificity mitogen-activated protein kinase kinase 4 isoform c
NM_001316369.1 NP_001303298.1 dual specificity mitogen-activated protein kinase kinase 4 isoform c
NM_001362739.1 NP_001349668.1 dual specificity mitogen-activated protein kinase kinase 4 isoform d
NM_001362740.1 NP_001349669.1 dual specificity mitogen-activated protein kinase kinase 4 isoform d
NM_009157.5 NP_033183.1 dual specificity mitogen-activated protein kinase kinase 4 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
10523642 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within MAPK cascade IPI
IPI: Inferred from physical interaction
12556533 MGI
involved in intrinsic apoptotic signaling pathway in response to hydrogen peroxide IDA
IDA: Inferred from direct assay
24705900 MGI
acts upstream of or within negative regulation of motor neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
25100604 MGI
acts upstream of or within response to wounding IMP
IMP: Inferred from mutant phenotype
25100604 MGI
involved in smooth muscle cell apoptotic process IDA
IDA: Inferred from direct assay
24705900 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

dual specificity mitogen-activated protein kinase kinase 4

  • C-JUN N-terminal kinase kinase 1

  • JNK kinase 1

  • JNK-activating kinase 1

  • MAP kinase kinase 4

  • MAPK/ERK kinase 4

  • SAPK/ERK kinase 1

  • SAPK/Erk/kinase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-159190 HRX-0233 98.92% Unkown
HY-RS16235 Map2k4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08040 MAP2K4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Map2k4 NCBI NCBI:6416