IL36RN - interleukin 36 receptor antagonist Gene

Also Known as FIL1; FIL1D; IL1F5; IL1L1; PSORP; IL1HY1; IL1RP3; IL36RA; IL-36Ra; PSORS14; FIL1(DELTA)

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 26525

About IL36RN

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:113,058,638-113,064,744 (from NCBI)

This gene has 4 transcripts (splice variants), 212 orthologues, 7 paralogues and is associated with 5 phenotypes. Biased expression in skin (RPKM 14.6), esophagus (RPKM 6.5) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight Other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]

IL36RN Products (2)

mRNA	Protein	Name
NM_012275.3	NP_036407.1	interleukin-36 receptor antagonist protein
NM_173170.1	NP_775262.1	interleukin-36 receptor antagonist protein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in antifungal humoral response	IMP IMP: Inferred from mutant phenotype	23147407	GOA
involved in negative regulation of cytokine-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	23147407	GOA
involved in negative regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	23147407	GOA
involved in negative regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	23147407	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL36RN Protein Structure

IL1

0
100
155 a.a.

Protein Preferred Names	Protein Names
interleukin-36 receptor antagonist protein	IL-1 related protein 3

IL36RN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL36RN	Q9UBH0	UBL4B	Homo sapiens	Q8N7F7	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	UBL4B	Homo sapiens	Q8N7F7	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	CRACR2B	Homo sapiens	Q8N4Y2-3	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	CNOT4	Homo sapiens	O95628-2	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	CNOT4	Homo sapiens	O95628-2	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	HPCA	Homo sapiens	P84074	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	HPCA	Homo sapiens	P84074	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	SH2B2	Homo sapiens	O14492-2	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	SH2B2	Homo sapiens	O14492-2	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	AP3M1	Homo sapiens	Q9Y2T2	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	AP3M1	Homo sapiens	Q9Y2T2	Validated Y2H	32296183
Intra	IL36RN	Q9UBH0	AP3M1	Homo sapiens	Q9Y2T2	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	ZKSCAN4	Homo sapiens	Q969J2	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	ZKSCAN4	Homo sapiens	Q969J2	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	SSBP3	Homo sapiens	Q9BWW4	Validated Y2H	25416956
Intra	IL36RN	Q9UBH0	SSBP3	Homo sapiens	Q9BWW4	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	SSBP3	Homo sapiens	Q9BWW4	Y2H Array	25416956
Intra	IL36RN	Q9UBH0	SSBP3	Homo sapiens	Q9BWW4	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	SSBP3	Homo sapiens	Q9BWW4	Y2H Prey Pooling	25416956
Intra	IL36RN	Q9UBH0	REL	Homo sapiens	Q04864	Y2H Array	25416956
Intra	IL36RN	Q9UBH0	INCA1	Homo sapiens	Q0VD86	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	INCA1	Homo sapiens	Q0VD86	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	AGR2	Homo sapiens	O95994	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	AGR2	Homo sapiens	O95994	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	IL36RN	Q9UBH0	SSBP4	Homo sapiens	Q9BWG4	Y2H Pooling	16189514
Intra	IL36RN	Q9UBH0	SSBP4	Homo sapiens	Q9BWG4	Y2H Prey Pooling	32296183
Intra	IL36RN	Q9UBH0	SSBP4	Homo sapiens	Q9BWG4	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL36RN Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71965	IL-36RN Protein, Human	Q9UBH0 (V2-D155)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700127AF	Animal-Free IL-36RN Protein, Human (His)	Q9UBH0 (M1-T108)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Psoriasis 14, Pustular	Generalized Pustular Psoriasis Gpp Ditra Acrodermatitis Continua Of Hallopeau Palmoplantar Pustulosis PSORS14 Interleukin 36 Receptor Antagonist Deficiency Psorp Pustular Psoriasis 14 Deficiency Of Il-36r Antagonist Acute Generalised Pustular Psoriasis Deficiency Of The Interleukin-36 Receptor Antagonist Generalized Pustular Psoriasis Of Von Zumbusch Von Zumbusch Psoriasis Deficiency Of Il-36ra Psoriasis, Pustular, Generalized Psoriasis, Pustular, Type 14 Pustulosis Of Palms And Soles Acute Generalized Pustular Psoriasis Palmoplantar Pustular Psoriasis Pustulosis Palmaris Et Plantaris Ppp - [Palmoplantar Pustulosis] Pustular Psoriasis Of The Palms And Soles Pustular Bacterid
Autoinflammatory Syndrome
Periodontitis, Aggressive, 1	Pustulosis Palmaris Et Plantaris Ppp Periodontitis, Juvenile Localized Pustular Psoriasis Jpd Periodontitis 1, Juvenile Lpp Palmoplantar Pustulosis Prepubertal Periodontitis Periodontitis, Aggressive 1 Periodontitis, Prepubertal Periodontititis, Aggressive, 1 AP1 Juvenile Periodontitis Periodontitis Juvenile Pustulosis Of Palms And Soles Generalized Pustular Psoriasis
Acrodermatitis
Acute Generalized Exanthematous Pustulosis	Agep Pustular Drug Eruption Toxic Pustuloderma
Impetigo
Geographic Tongue	Benign Migratory Glossitis Glossitis Areata Exfoliativa Glossitis, Benign Migratory Pityriasis Linguae Ectopic Geographic Tongue Erythema Migrans Erythema Chronicum Migrans Benign Migrating Glossitis Geographical Tongue Lingua Geographica Erythema Migrans Of Tongue Wandering Rash Of Tongue
Atrophic Glossitis	Atrophy Of Tongue Papillae Glossitis, Hunter'S Hunter'S Glossitis Smooth Atrophic Tongue Hunter Glossitis Central Papillary Atrophy Of The Tongue
Impetigo Herpetiformis
Pustulosis Of Palm And Sole	Psoriasis Acropustulosis Palmoplantar Pustulosis Pustular Psoriasis Of The Palms And/Or Soles Pustulosis Of Palms And Soles Acrodermatitis Continua Of Hallopeau Generalized Pustular Psoriasis
Psoriasis
Pityriasis Rubra Pilaris	PRP Devergie'S Disease Prp - [Pityriasis Rubra Pilaris]
Erythema Elevatum Diutinum
Alopecia Areata	Aa Alopecia Celsi Alopecia Circumscripta Cazenave'S Vitiligo Celsus' Vitiligo Diffuse Alopecia Jonston'S Alopecia Marginal Alopecia Pseudopelade Circumscribed Alopecia Alopecia Cicatrisata Patchy Alopecia Alopecia Aa - [Alopecia Areata] Pelade
Psoriasis 13	PSORS13 Psoriasis 13, Susceptibility To Psoriasis Psoriasis Vulgaris Psoriasis Susceptibility 13 Pv Psoriasis, Susceptibility To, Type 13
Pulmonary Hemosiderosis	Idiopathic Pulmonary Hemosiderosis Alveolar Hypoventilation Syndrome Brown Induration Brown Lung Siderosis Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin Byssinosis
Psoriasis 15	Psors15
Periostitis
Psoriasis 3	PSORS3 Psoriasis Susceptibility 3 Psoriasis 3, Susceptibility To
Glossitis	Inflammation Of Tongue Tongue Inflammation Glazed Tongue
Periodic Fever, Familial, Autosomal Dominant	Familial Hibernian Fever Tumor Necrosis Factor Receptor-Associated Periodic Syndrome Traps FPF Tnf Receptor-Associated Periodic Fever Syndrome Hibernian Fever, Familial Fhf Tnf Receptor-Associated Periodic Syndrome Autosomal Dominant Familial Periodic Fever Periodic Fever, Familial Tnf Receptor 1-Associated Periodic Syndrome Tumor Necrosis Factor Receptor 1 Associated Periodic Syndrome Familial Periodic Fever Traps Syndrome Tnf Receptor Associated Periodic Syndrome Caledonian Fever Fever, Periodic, Familial Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
Autoimmune Disease Of Skin And Connective Tissue
Neutrophilic Dermatosis, Acute Febrile	Sweet Syndrome Acute Febrile Neutrophilic Dermatosis Ss AFND Pyrin-Associated Autoinflammatory Disease PAAND Gomm-Button Disease Sweet'S Syndrome Gomm Button Disease Sweets Syndrome Acromelic Frontonasal Dysostosis Sweet Disease
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne	Papa Syndrome Fra Familial Recurrent Arthritis Pyogenic Arthritis, Pyoderma Gangrenosum And Acne PAPAS Pyogenic Arthritis-Pyoderma Gangrenosum-Acne Syndrome Pyogenic Arthritis, Pyoderma Gangrenosum, And Severe Cystic Acne Pyogenic Sterile Arthritis, Pyoderma Gangrenosum And Acne
Pyoderma
Cinca Syndrome	CINCA Nomid Cryopyrin-Associated Periodic Syndrome 3 Chronic Neurologic Cutaneous And Articular Syndrome Multisystem Inflammatory Disease, Neonatal-Onset Caps3 Chronic Infantile Neurological Cutaneous Articular Syndrome Infantile-Onset Multisystem Inflammatory Disease Iomid Syndrome Neonatal-Onset Multisystem Inflammatory Disease Nomid Syndrome Prieur-Griscelli Syndrome Neonatal Onset Multisystem Inflammatory Disease Chronic Infantile Neurological, Cutaneous And Articular Syndrome Iomid Infantile Onset Multisystem Inflammatory Disease Prieur Griscelli Syndrome Chronic Infantile Neurological Cutaneous And Articular Syndrome Chronic, Infantile, Neurological, Cutaneous, Articular Syndrome Chronic Infantile Neurologic Cutaneous And Articular Syndrome Chronic Infantile Neurological, Cutaneous, And Articular Syndrome Cryopyrin-Associated Periodic Syndromes
Psoriasis 11	PSORS11 Psoriasis Susceptibility 11 Psoriasis Psoriasis Vulgaris Psoriasis 11, Susceptibility To Pv
Behcet Syndrome	Behcet Disease Behcet'S Syndrome Behcet'S Disease Behçet Disease Bd Adamantiades-Behcet Disease Triple Symptom Complex Behçet'S Disease Behet'S Syndrome Bd Syndrome Behçet Syndrome Behçet'S Syndrome Behcet Triple Symptom Complex Malignant Aphthosis Old Silk Route Disease Adamantiades-Behçet Disease
Skin Disease	Skin Diseases Genodermatosis Abnormality Of The Skin Skin Diseases, Genetic Skin And Subcutaneous Tissue Disease Dermatologic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06762	IL36RN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18867	Il36rn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25358	Il36rn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	IL36RN	VGNC	VGNC:41985
Mus musculus	IL36RN	MGD	MGI:1859325
Rattus norvegicus	IL36RN	RGD	RGD:1311212
Macaca mulatta	IL36RN	VGNC	VGNC:106173
Bos taurus	IL36RN	VGNC	VGNC:30159
Others	IL36RN	NCBI