GGT5 - gamma-glutamyltransferase 5 Gene

Homo sapiens

Also known as GGL; GGT 5; GGTLA1; GGT-REL

Gene ID: 2687 | Gene type: protein coding

About GGT5

Cytogenetic location: 22q11.23 Genomic coordinates (GRCh38): 22:24,219,654-24,245,142 (from NCBI)

This gene has 6 transcripts (splice variants), 343 orthologues and 6 paralogues. Ubiquitous expression in fat (RPKM 18.6), kidney (RPKM 15.2) and 24 other tissues.

Summary

This gene is a member of the gamma-glutamyl transpeptidase gene family, and some reports indicate that it is capable of cleaving the gamma-glutamyl moiety of glutathione. The protein encoded by this gene is synthesized as a single, catalytically-inactive polypeptide, that is processed post-transcriptionally to form a heavy and LIGHT subunit, with the catalytic activity contained within the small subunit. The encoded Enzyme is able to convert leukotriene C4 to leukotriene D4, but appears to have distinct substrate specificity compared to gamma-glutamyl transpeptidase. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

GGT5 Products(5)

mRNA	Protein	Name
NM_001099781.2	NP_001093251.1	glutathione hydrolase 5 proenzyme isoform 1
NM_001099782.2	NP_001093252.1	glutathione hydrolase 5 proenzyme isoform 3
NM_001302464.1	NP_001289393.1	glutathione hydrolase 5 proenzyme isoform 4
NM_001302465.1	NP_001289394.1	glutathione hydrolase 5 proenzyme isoform 5
NM_004121.5	NP_004112.2	glutathione hydrolase 5 proenzyme isoform 2

GGT5 Protein Structure

G_glu_transpept

0
100
200
300
400
500
586 a.a.

Protein Preferred Names

Protein Names

glutathione hydrolase 5 proenzyme

gamma-glutamyl cleaving enzyme

Recombinant GGT5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76361	GGT5 Protein, Human (HEK293, His)	P36269-1/NP_004112.2 (S30-Y586)	≥95%

Related Diseases

Diseases

Alias

Glutathionuria

Gamma-Glutamyltransferase Deficiency	Ggt Deficiency
Gtg Deficiency	Gamma-Glutamyltranspeptidase Deficiency
Glutathioninuria	Gamma-Glutamyl Transpeptidase Deficiency
Gamma-Glutamyl Transferase Deficiency	Ggt1 Deficiency
GLUTH

Capillariasis

Capillaria Infection	Enoplida Infections
Capillariasis Nos	Capillariosis

Retinitis Pigmentosa 43

RP43	Retinitis Pigmentosa, Type 43

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05404	GGT5 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GGT5	MGD	MGI:1346063
Rattus norvegicus	GGT5	RGD	RGD:2684
Bos taurus	GGT5	VGNC	VGNC:29344
Felis catus	GGT5	VGNC	VGNC:62540
Others	GGT5	NCBI