CACNG5 - calcium voltage-gated channel auxiliary subunit gamma 5 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 27091

About CACNG5

Cytogenetic location: 17q24.2 Genomic coordinates (GRCh38): 17:66,835,117-66,894,751 (from NCBI)

This gene has 3 transcripts (splice variants), 116 orthologues and 5 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a type II transmembrane AMPA Receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a Calcium Channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]

CACNG5 Products (2)

mRNA Protein Name
NM_001371476.1 NP_001358405.1 voltage-dependent calcium channel gamma-5 subunit isoform 2
NM_145811.3 NP_665810.1 voltage-dependent calcium channel gamma-5 subunit isoform 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
18817736 GOA
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
18817736 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CACNG5 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (11 - 195)

  • 0
  • 100
  • 200
  • 275 a.a.
Protein Preferred Names Protein Names

voltage-dependent calcium channel gamma-5 subunit

  • TARP gamma-5

Related Diseases

Diseases Alias
Spinal Cord Ependymoma

  • Ependymal Neoplasm Of The Spinal Cord

  • Spinal Ependymoma

  • Ependymoma Of Spinal Cord
Bipolar Disorder

  • Bipolar Depression

  • Manic Disorder

  • Depression, Bipolar

  • Bipolar Disorder Manic Phase

  • Depressive-Manic Psych.

  • Manic Bipolar Affective Disorder

  • Manic Bipolar I Disorder

  • Manic Depression

  • Manic Depressive Disorder

  • Mixed Bipolar Disorder

  • Bipolar Affective Disorder

  • Bipolar Affective Psychosis

  • Bipolar Spectrum Disorder

  • Manic Depressive Illness

  • Depression Bipolar

  • Bipolar Disorder, Mixed

  • Major Affective Disorder

  • Major Affective Disorder 1

  • Major Affective Disorder 2
Spinal Cord Glioma

  • Glial Tumor Of Spinal Cord

  • Glial Neoplasm Spinal Cord

  • Glioma Of Spinal Cord
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Dyskeratosis Congenita, Autosomal Recessive 2

  • DKCB2

  • Autosomal Recessive Dyskeratosis Congenita 2

  • Dyskeratosis Congenita, Autosomal Recessive, 2

  • Dyskeratosis Congenita, Autosomal Recessive, Type 2
Spinal Cancer

  • Spinal Cord Neoplasm

  • Spinal Cord Neoplasms

  • Spinal Neoplasms

  • Intraspinal Tumor

  • Malignant Tumor Of The Spinal Cord

  • Spinal Cord Cancer

  • Spinal Neoplasm

  • Tumor Of The Spinal Cord

  • Tumors Spinal Cord

  • Intraspinal Neoplasm

  • Spinal Cord--Cancer
Arrhythmogenic Right Ventricular Cardiomyopathy

  • Arrhythmogenic Right Ventricular Dysplasia

  • Arvc

  • Arvd

  • Arrhythmogenic Right Ventricular Dysplasia/Cardiomyopathy

  • Arvc Cardiomyopathy

  • Arrhythmogenic Right Ventricular Cardiomyopathy-Dysplasia

  • Arvd/C

  • Right Ventricular Dysplasia, Arrhythmogenic

  • Ventricular Dysplasia, Right, Arrhythmogenic

  • Cardiomyopathy, Ventricular, Right, Arrhythmogenic

  • Dysplasia, Arrhythmogenic Right Ventricular
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01813 CACNG5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus CACNG5 VGNC VGNC:60311
Bos taurus CACNG5 VGNC VGNC:26690
Mus musculus CACNG5 MGD MGI:2157946
Rattus norvegicus CACNG5 RGD RGD:628805
Macaca mulatta CACNG5 VGNC VGNC:104589
Canis familiaris CACNG5 VGNC VGNC:38650
Others CACNG5 NCBI