HCAR1 - hydroxycarboxylic acid receptor 1 Gene
Also Known as HCA1; GPR81; LACR1; FKSG80; GPR104; TAGPCR; TA-GPCR
Species: Homo sapiens
Gene Type: protein coding
Gene ID: 27198
About HCAR1
Cytogenetic location: 12q24.31
Genomic coordinates (GRCh38): 12:122,726,076-122,730,844 (from NCBI)
This gene has 1 transcript (splice variant), 172 orthologues and 15 paralogues.
Summary
G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]
HCAR1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_032554.4 | NP_115943.1 | hydroxycarboxylic acid receptor 1 |
HCAR1 Protein Structure
7tm_1
7tm_1: 7 transmembrane receptor (rhodopsin family) (32 - 278)
- 0
- 100
- 200
- 300
- 346 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
hydroxycarboxylic acid receptor 1 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Pellagra |
|
|
| Diversion Colitis |
|
Related Agents
- Approval
- Pre-clinical Phase
Approval
Bioactive Molecules
(3)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-B2227B | Lactic acid sodium (60% w/w in water) | Activator | 98.0% | Unkown |
| HY-B2227 | Lactic acid | Activator | / | Unkown |
| HY-B2227A | Lactic acid calcium | Activator | 98.5% | Yes |
Pre-clinical Phase
Bioactive Molecules
(2)
| Cat. No. | Product Name |
Effect
|
Purity |
Rare Diseases
|
|---|---|---|---|---|
| HY-W016868 | 3-Chloro-5-hydroxybenzoic acid | Agonist | 99.54% | Unkown |
| HY-W015560 | 3,5-Dihydroxybenzoic acid | Agonist | 99.98% | Unkown |
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | HCAR1 | MGD | MGI:2441671 |
| Canis familiaris | HCAR1 | VGNC | VGNC:41613 |
| Bos taurus | HCAR1 | VGNC | VGNC:29769 |
| Rattus norvegicus | HCAR1 | RGD | RGD:1586364 |
| Others | HCAR1 | NCBI |
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