Amot - angiomotin Gene

Also Known as Sii6; CAG-2; D0Kist1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 27494

Summary

Predicted to enable angiostatin binding activity and signaling receptor activity. Acts upstream of or within several processes, including ameboidal-type cell migration; negative regulation of GTPase activity; and vasculogenesis. Located in bicellular tight junction; cytoplasmic vesicle; and lamellipodium. Is expressed in several structures, including egg cylinder; embryo endoderm; embryo mesoderm; and mesendoderm. Orthologous to human AMOT (angiomotin). [provided by Alliance of Genome Resources, Apr 2022]

Amot Products (6)

mRNA Protein Name
NM_001290274.2 NP_001277203.1 angiomotin isoform 2
NM_001403386.1 NP_001390315.1 angiomotin isoform 3
NM_001403387.1 NP_001390316.1 angiomotin isoform 1
NM_001403388.1 NP_001390317.1 angiomotin isoform 1
NM_001403389.1 NP_001390318.1 angiomotin isoform 3
NM_153319.4 NP_695231.3 angiomotin isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17397395 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
17699752 MGI
acts upstream of or within blood vessel endothelial cell migration IMP
IMP: Inferred from mutant phenotype
17699752 MGI
acts upstream of or within blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
17699752 MGI
acts upstream of or within cell migration involved in gastrulation IMP
IMP: Inferred from mutant phenotype
12676095 MGI
acts upstream of or within chemotaxis IMP
IMP: Inferred from mutant phenotype
12902404 MGI
acts upstream of embryo development IMP
IMP: Inferred from mutant phenotype
12676095 MGI
acts upstream of or within establishment of cell polarity involved in ameboidal cell migration IMP
IMP: Inferred from mutant phenotype
17699752 MGI
acts upstream of or within gastrulation with mouth forming second IMP
IMP: Inferred from mutant phenotype
12676095 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
12676095 MGI
acts upstream of or within negative regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
17699752 MGI
acts upstream of or within positive regulation of embryonic development IMP
IMP: Inferred from mutant phenotype
12676095 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
18824598 MGI
acts upstream of or within regulation of small GTPase mediated signal transduction IMP
IMP: Inferred from mutant phenotype
17699752 MGI
acts upstream of or within vasculogenesis IMP
IMP: Inferred from mutant phenotype
12902404 MGI
Cellular Component GO Annotation Evidence References Source
located in bicellular tight junction IDA
IDA: Inferred from direct assay
17397395 MGI
located in cytoplasmic vesicle IDA
IDA: Inferred from direct assay
17397395 MGI
located in lamellipodium IDA
IDA: Inferred from direct assay
12902404 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiomotin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00663 AMOT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20691 Amot Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27202 Amot Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Amot NCBI NCBI:154796