Prex1 - phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 Gene

Also Known as Setd6; P-REX1; G630042G04

Species: Mus musculus

Gene Type: protein coding
Gene ID: 277360

Summary

Predicted to enable phospholipid binding activity. Acts upstream of or within several processes, including neutrophil chemotaxis; positive regulation of GTPase activity; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Is expressed in several structures, including liver; nervous system; palatal shelf; skeleton; and testis. Used to study autism spectrum disorder. Orthologous to human PREX1 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Prex1 Products (2)

mRNA Protein Name
NM_177782.3 NP_808450.2 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein
NM_177782.3 NP_808450.2 phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
acts upstream of or within G protein-coupled receptor signaling pathway IGI
IGI: Inferred from genetic interaction
21178006 MGI
acts upstream of or within T cell differentiation IGI
IGI: Inferred from genetic interaction
21178006 MGI
acts upstream of or within neutrophil chemotaxis IGI
IGI: Inferred from genetic interaction
21179475 MGI
acts upstream of or within positive regulation of GTPase activity IGI
IGI: Inferred from genetic interaction
21178006 MGI
acts upstream of or within positive regulation of cell adhesion IGI
IGI: Inferred from genetic interaction
21178006 MGI
acts upstream of or within positive regulation of substrate adhesion-dependent cell spreading IGI
IGI: Inferred from genetic interaction
21178006 MGI
acts upstream of or within reactive oxygen species metabolic process IGI
IGI: Inferred from genetic interaction
21179475 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein

  • SET domain containing 6

  • ptdIns(3,4,5)-dependent Rac exchanger 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-104064 1A-116 99.72% Unkown
HY-RS11085 PREX1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21697 Prex1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28215 Prex1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prex1 NCBI NCBI:57580