Nsun2 - NOL1/NOP2/Sun domain family member 2 Gene

Also Known as Misu; D13Wsu123e

Species: Mus musculus

Gene Type: protein coding
Gene ID: 28114

Summary

Enables mRNA (cytidine-5-)-methyltransferase activity and tRNA (cytosine-5-)-methyltransferase activity. Involved in several processes, including RNA methylation; meiotic cell cycle checkpoint signaling; and tRNA stabilization. Acts upstream of or within in utero embryonic development. Located in chromatoid body. Is expressed in several structures, including branchial arch; cardiovascular system; central nervous system; extraembryonic component; and sensory organ. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability. Orthologous to human NSUN2 (NOP2/Sun RNA methyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Nsun2 Products (1)

mRNA Protein Name
NM_145354.5 NP_663329.3 RNA cytosine C(5)-methyltransferase NSUN2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA (cytidine-5-)-methyltransferase activity IDA
IDA: Inferred from direct assay
23871666 MGI
enables tRNA (cytidine-5-)-methyltransferase activity IDA
IDA: Inferred from direct assay
23871666 MGI
enables tRNA (cytidine-5-)-methyltransferase activity IMP
IMP: Inferred from mutant phenotype
22885326 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within hair follicle maturation IMP
IMP: Inferred from mutant phenotype
25340873 MGI
involved in hair follicle maturation IMP
IMP: Inferred from mutant phenotype
22144916 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
27996060 MGI
involved in mRNA processing IDA
IDA: Inferred from direct assay
23871666 MGI
involved in meiotic cell cycle checkpoint signaling IMP
IMP: Inferred from mutant phenotype
23401851 MGI
involved in regulation of stem cell differentiation IMP
IMP: Inferred from mutant phenotype
22144916 MGI
involved in spermatid development IMP
IMP: Inferred from mutant phenotype
23401851 MGI
involved in tRNA methylation IDA
IDA: Inferred from direct assay
31276587 MGI
involved in tRNA methylation IMP
IMP: Inferred from mutant phenotype
22144916 MGI
involved in tRNA processing IDA
IDA: Inferred from direct assay
23871666 MGI
involved in tRNA stabilization IMP
IMP: Inferred from mutant phenotype
22885326 MGI
Cellular Component GO Annotation Evidence References Source
located in chromatoid body IDA
IDA: Inferred from direct assay
23401851 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RNA cytosine C(5)-methyltransferase NSUN2

  • Myc-induced SUN domain containing protein

  • NOL1/NOP2/Sun domain family 2

  • mRNA cytosine C(5)-methyltransferase

  • myc-induced SUN domain-containing protein

  • tRNA (cytosine(34)-C(5))-methyltransferase

  • tRNA (cytosine-5-)-methyltransferase NSUN2

  • tRNA cytosin

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-158301 MY-1B Inhibitor 99.94% Unkown
HY-RS29442 Nsun2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09601 NSUN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181962 ZINC-1000507789 Inhibitor / Unkown
HY-181963 ZINC-1000507824 / Unkown
HY-RS24549 Nsun2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nsun2 NCBI NCBI:54888