XCR1 - X-C motif chemokine receptor 1 Gene

Also Known as GPR5; CCXCR1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2829

About XCR1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,017,007-46,085,844 (from NCBI)

This gene has 3 transcripts (splice variants), 302 orthologues and 23 paralogues. Biased expression in lymph node (RPKM 2.0), spleen (RPKM 1.4) and 12 other tissues.

Summary

The protein encoded by this gene is a Chemokine Receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved Amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2020]

XCR1 Products (3)

mRNA Protein Name
NM_001024644.2 NP_001019815.1 chemokine XC receptor 1
NM_001381860.1 NP_001368789.1 chemokine XC receptor 1
NM_005283.3 NP_005274.1 chemokine XC receptor 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XCR1 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (48 - 287)

  • 0
  • 100
  • 200
  • 300
  • 333 a.a.
Protein Preferred Names Protein Names

chemokine XC receptor 1

  • G protein-coupled receptor 5

XCR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
XCR1 P46094 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra
XCR1 P46094 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
XCR1 P46094 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15868 XCR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174506 Human XCR1 mRNA / Unkown
HY-RS19654 Xcr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26147 Xcr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus XCR1 VGNC VGNC:67103
Bos taurus XCR1 VGNC VGNC:36983
Canis familiaris XCR1 VGNC VGNC:48447
Macaca mulatta XCR1 VGNC VGNC:79016
Mus musculus XCR1 MGD MGI:1346338
Rattus norvegicus XCR1 RGD RGD:1311480
Others XCR1 NCBI