XCR1 - X-C motif chemokine receptor 1 Gene

Homo sapiens

Also known as GPR5; CCXCR1

Gene ID: 2829 | Gene type: protein coding

About XCR1

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:46,017,007-46,085,844 (from NCBI)

This gene has 3 transcripts (splice variants), 302 orthologues and 23 paralogues. Biased expression in lymph node (RPKM 2.0), spleen (RPKM 1.4) and 12 other tissues.

Summary

The protein encoded by this gene is a Chemokine Receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved Amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Several alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2020]

XCR1 Products(3)

mRNA	Protein	Name
NM_001024644.2	NP_001019815.1	chemokine XC receptor 1
NM_001381860.1	NP_001368789.1	chemokine XC receptor 1
NM_005283.3	NP_005274.1	chemokine XC receptor 1

XCR1 Protein Structure

7tm_1

0
100
200
300
333 a.a.

Protein Preferred Names

Protein Names

chemokine XC receptor 1

G protein-coupled receptor 5

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15868	XCR1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	XCR1	VGNC	VGNC:67103
Bos taurus	XCR1	VGNC	VGNC:36983
Canis familiaris	XCR1	VGNC	VGNC:48447
Macaca mulatta	XCR1	VGNC	VGNC:79016
Mus musculus	XCR1	MGD	MGI:1346338
Rattus norvegicus	XCR1	RGD	RGD:1311480