GPR6 - G protein-coupled receptor 6 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2830

About GPR6

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:109,978,311-109,980,720 (from NCBI)

This gene has 2 transcripts (splice variants), 186 orthologues and 18 paralogues. Low expression observed in reference dataset.

Summary

Predicted to enable sphingosine-1-phosphate receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within positive regulation of cytosolic calcium ion concentration. Predicted to be integral component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR6 Products (2)

mRNA Protein Name
NM_005284.5 NP_005275.1 G-protein coupled receptor 6 isoform b
NM_001286099.2 NP_001273028.1 G-protein coupled receptor 6 isoform a

GPR6 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (89 - 329)

  • 0
  • 100
  • 200
  • 300
  • 362 a.a.
Protein Preferred Names Protein Names

G-protein coupled receptor 6

  • sphingosine 1-phosphate receptor GPR6

Related Diseases

Diseases Alias
Lennox-Gastaut Syndrome

  • Epileptic Encephalopathy Lennox-Gastaut Type

  • Lennox Syndrome

  • Encephalopathy Of Childhood

  • Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves

  • Lgs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-134661A Solangepras 99.70% Phase 3

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-134661 (S)-CVN424 99.16% Unkown
HY-182011 GPR6 inverse agonist 2 Agonist / Unkown
HY-181349 GPR6 inverse agonist 1 Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus GPR6 MGD MGI:2155249
Canis familiaris GPR6 VGNC VGNC:41439
Felis catus GPR6 VGNC VGNC:67435
Bos taurus GPR6 VGNC VGNC:29592
Macaca mulatta GPR6 VGNC VGNC:73139
Rattus norvegicus GPR6 RGD RGD:70939
Others GPR6 NCBI