(S)-Solangepras
Based on 1 Customer Validation
(S)-CVN424 is a potent G-Protein-Coupled Receptor 6 (GPR6) modulator. (S)-CVN424 has the potential for a variety of neurological and psychiatric disorders research, including Parkinson's disease.
For research use only. We do not sell to patients.
- Purity : 99.16%
- CAS No.: 1799968-74-3
- Formula: C24H29F2N5O3
- Molecular Weight:473.52
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
GPR6[1]
In Vitro
(S)-CVN424 (example 149) inhibits cAMP activity with an IC50 of 58.7 μM in CHO-K1 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 1799968-74-3
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Appearance Solid
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Molecular Weight 473.52
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Formula C24H29F2N5O3
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Color White to off-white
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SMILES
CC(N1CCC2=NC(N3CCC(OC4=CC=C(F)C=C4F)CC3)=C(N[C@@H]5COCC5)N=C2C1)=O
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Synonyms
(S)-CVN424
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 25 mg/mL (52.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
Purity & Documentation
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Data Sheet (279 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.1118 mL | 10.5592 mL | 21.1184 mL | 52.7961 mL |
| 5 mM | 0.4224 mL | 2.1118 mL | 4.2237 mL | 10.5592 mL | |
| 10 mM | 0.2112 mL | 1.0559 mL | 2.1118 mL | 5.2796 mL | |
| 15 mM | 0.1408 mL | 0.7039 mL | 1.4079 mL | 3.5197 mL | |
| 20 mM | 0.1056 mL | 0.5280 mL | 1.0559 mL | 2.6398 mL | |
| 25 mM | 0.0845 mL | 0.4224 mL | 0.8447 mL | 2.1118 mL | |
| 30 mM | 0.0704 mL | 0.3520 mL | 0.7039 mL | 1.7599 mL | |
| 40 mM | 0.0528 mL | 0.2640 mL | 0.5280 mL | 1.3199 mL | |
| 50 mM | 0.0422 mL | 0.2112 mL | 0.4224 mL | 1.0559 mL |
(S)-Solangepras Related Classifications
HY-134661 Related Classifications
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