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CVN424 

Cat. No.: HY-134661A
Handling Instructions

CVN424 is an orally active and selective GPR6 inverse agonist with a EC50 of 9.4 nM and an EC50 of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research.

For research use only. We do not sell to patients.

CVN424 Chemical Structure

CVN424 Chemical Structure

CAS No. : 2254706-21-1

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Description

CVN424 is an orally active and selective GPR6 inverse agonist with a EC50 of 9.4 nM and an EC50 of 38 nM. CVN424 is brain-penetrant and has the potential for Parkinson disease research[1][2].

IC50 & Target

GPR6[1]

In Vitro

CVN424 (Compound 6i) has 265 fold and 68 fold selectivities over GPR3 and GPR12[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

473.52

Formula

C₂₄H₂₉F₂N₅O₃

CAS No.
SMILES

FC1=C(OC2CCN(C3=NC4=C(N=C3N[[email protected]]5COCC5)CN(CC4)C(C)=O)CC2)C=CC(F)=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

CVN424CVN 424CVN-424OthersorallyGPR6brainpenetrantParkinsondiseaseInhibitorinhibitorinhibit

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